On the path to [Fe-S] protein maturation: A personal perspective.

Autor: Dean DR; Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061-0346, United States of America. Electronic address: deandr@vt.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Aug; Vol. 1871 (6), pp. 119750. Date of Electronic Publication: 2024 May 16.
DOI: 10.1016/j.bbamcr.2024.119750
Abstrakt: Azotobacter vinelandii is a genetically tractable Gram-negative proteobacterium able to fix nitrogen (N2) under aerobic growth conditions. This narrative describes how biochemical-genetic approaches using A. vinelandii to study nitrogen fixation led to the formulation of the "scaffold hypothesis" for the assembly of both simple and complex [Fe-S] clusters associated with biological nitrogen fixation. These studies also led to the discovery of a parallel, but genetically distinct, pathway for maturation of [Fe-S] proteins that support central metabolic processes.
Competing Interests: Declaration of competing interest The author declares that he has no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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