Current understanding of the role of DDX21 in orchestrating gene expression in health and diseases.

Autor: Wang S; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Yang R; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Song M; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China., Li J; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; City of Hope Medical Center, Duarte, CA 91010, USA; Division of Stem Cell Biology Research, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010, USA., Zhou Y; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: yrzhou@mail.hzau.edu.cn., Dai C; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, China. Electronic address: cdai26@tjh.tjmu.edu.cn., Song T; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: songtongxing@mail.hzau.edu.cn.
Jazyk: angličtina
Zdroj: Life sciences [Life Sci] 2024 Jul 15; Vol. 349, pp. 122716. Date of Electronic Publication: 2024 May 16.
DOI: 10.1016/j.lfs.2024.122716
Abstrakt: RNA helicases are involved in almost all biological events, and the DDXs family is one of the largest subfamilies of RNA helicases. Recently, studies have reported that RNA helicase DDX21 is involved in several biological events, specifically in orchestrating gene expression. Hence, in this review, we provide a comprehensive overview of the function of DDX21 in health and diseases. In the genome, DDX21 contributes to genome stability by promoting DNA damage repair and resolving R-loops. It also facilitates transcriptional regulation by directly binding to promoter regions, interacting with transcription factors, and enhancing transcription through non-coding RNA. Moreover, DDX21 is involved in various RNA metabolism such as RNA processing, translation, and decay. Interestingly, the activity and function of DDX21 are regulated by post-translational modifications, which affect the localization and degradation of DDX21. Except for its role of RNA helicase, DDX21 also acts as a non-enzymatic function in unwinding RNA, regulating transcriptional modifications and promoting transcription. Next, we discuss the potential application of DDX21 as a clinical predictor for diseases, which may facilitate providing novel pharmacological targets for molecular therapy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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