The role of metabolic syndrome as a mediator in the relationship between CCL11 levels and the presence of a mood episode with mixed features in young adults with bipolar disorder.

Autor: Bender LV; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Wirowski N; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Lobato AS; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Jansen K; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Cardoso TA; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia., Mondin TC; Pro-rectory of Student Affairs, Federal University of Pelotas, RS, Brazil., Oses JP; Post Graduation Program in Biochemistry and Prospecting. Visiting Researcher, Federal University of Pelotas, Pelotas, RS, Brazil., Kapczinski F; Bipolar Disorder Program, Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil; Department of Psychiatry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Mood disorders Program, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Porto Alegre, RS, Brazil., Souza LDM; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Silva RAD; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil., Pedrotti Moreira F; Post Graduation Program in Health and Behavior, Catholic University of Pelotas, Pelotas, RS, Brazil. Electronic address: fepedrotti@gmail.com.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2024 Jul; Vol. 175, pp. 343-349. Date of Electronic Publication: 2024 May 03.
DOI: 10.1016/j.jpsychires.2024.05.001
Abstrakt: Mixed features presentation in bipolar disorder (BD) represents the most severe form of the disease. BD may lead to cognitive and functional deterioration, a process known as neuroprogression, which appears to be exacerbated by increased serum levels of CCL11, a neuroprogression-related cytokine. Metabolic syndrome (MetS) is highly prevalent in BD, and it is known that the presence of MetS may increase inflammation, which may contribute to increased CCL11 levels, and consequently impact on the severity of the disorder. What is not known is whether the MetS mediates the association between CCL11 levels and the presence of mood episodes with mixed features in BD. Therefore, the aim of this study was to investigate the mediating effect of MetS on the relationship between CCL11 levels and the presence of mood episodes with mixed features in BD, in a population-based study. This is a cross-sectional study that included 184 young adults, 92 with BD and 92 populational controls, matched by sex and age. BD diagnosis was assessed using the Mini International Neuropsychiatric Interview - PLUS. Mood episodes with mixed features was defined according to DSM-IV and DSM-5 criteria. MetS was defined according to the National Cholesterol Education Program (NCEP/ATP III). Substance use was assessed through the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST). CCL11 serum levels were analyzed using the multiplex analysis method Luminex 200™ system. The mediation model was tested using the MedMod module of the JAMOVI 2.4.8 software. Mediation analysis indicated a trend towards significance of MetS mediating the association between CCL11 and the presence of a mood episode with mixed features in BD (p = 0.065). Individuals with BD presenting with a mood episode with mixed features and MetS may have accelerated neuroprogression due to the influence of MetS on CCL11 levels, therefore, assessing for MetS occurrence in this population and implementing early interventions to prevent its development may be effective ways of delaying cognitive impairments related to this cytokine.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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