Higher plant-derived nitrate intake is associated with lower odds of frailty in a cross-sectional study of community-dwelling older women.

Autor: Hayes E; Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK., Dent E; Research Centre for Public Health, Equity and Human Flourishing, Torrens University Australia, Adelaide, South Australia, Australia., Shannon OM; Human Nutrition and Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK., Zhong LZ; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia., Bozanich T; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia., Blekkenhorst LC; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia.; Medical School, The University of Western Australia, Perth, WA, Australia., Zhu K; Medical School, The University of Western Australia, Perth, WA, Australia.; Deparment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia., Bondonno CP; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia.; Medical School, The University of Western Australia, Perth, WA, Australia., Siervo M; School of Public Health, Curtin University, Perth, WA, Australia., Hoogendijk EO; Department of Epidemiology and Data Science, VU University Medical Center, Amsterdam UMC, Amsterdam, Netherlands.; Ageing and Later Life Research Program, Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, Netherlands., Hodgson JM; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia.; Medical School, The University of Western Australia, Perth, WA, Australia., Prince RL; Medical School, The University of Western Australia, Perth, WA, Australia., Lewis JR; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia.; Medical School, The University of Western Australia, Perth, WA, Australia., Sim M; Nutrition and Health Innovation Research Institute, School of Health and Medical Sciences, Edith Cowan University, Perth, WA, Australia. marc.sim@ecu.edu.au.; Medical School, The University of Western Australia, Perth, WA, Australia. marc.sim@ecu.edu.au.
Jazyk: angličtina
Zdroj: European journal of nutrition [Eur J Nutr] 2024 Sep; Vol. 63 (6), pp. 2281-2290. Date of Electronic Publication: 2024 May 18.
DOI: 10.1007/s00394-024-03412-z
Abstrakt: Purpose: Dietary nitrate intake is inversely related to numerous contributors towards frailty, including cardiovascular disease and poor physical function. Whether these findings extend to frailty remain unknown. We investigated if habitual nitrate intake, derived from plants or animal-based foods, was cross-sectionally associated with frailty in women.
Methods: Community-dwelling older Australian women (n = 1390, mean age 75.1 ± 2.7 years) completed a validated semi-quantitative food frequency questionnaire (FFQ). Nitrate concentrations in food were obtained from international nitrate databases. We adopted the Rockwood frailty index (FI) of cumulative deficits comprising 33 variables across multiple health domains (scored 0 to 1), which predicts increased hospitalisation and mortality risk. A FI ≥ 0.25 indicated frailty. Cross-sectional associations between nitrate intake (total plant and animal nitrate, separately) and frailty were analysed using multivariable-adjusted logistic regression models (including lifestyle factors), as part of restricted cubic splines.
Results: A non-linear inverse relationship was observed between total plant nitrate intake and frailty. Compared to women with the lowest plant nitrate intake (Quartile [Q]1), women with greater intakes in Q2 (OR 0.69 95%CI 0.56-0.84), Q3 (OR 0.67 95%CI 0.50-0.90) and Q4 (OR 0.66 95%CI 0.45-0.98) had lower odds for frailty. A nadir in the inverse association was observed once intakes reached ~ 64 mg/d (median Q2). No relationship was observed between total animal nitrate and frailty.
Conclusion: Community-dwelling older women consuming low amounts of plant-derived nitrate were more likely to present with frailty. Consuming at least one daily serving (~ 75 g) of nitrate-rich green leafy vegetables may be beneficial in preventing frailty.
(© 2024. The Author(s).)
Databáze: MEDLINE
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