Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples.

Autor: Schinkel ER; Mother's Milk is Best Inc., R&D, 100 Business Park Drive, Unit #5, Tyngsboro, MA, 01879, USA. beth@mothersmilkisbest.com., Nelson ER; Mother's Milk is Best Inc., R&D, 100 Business Park Drive, Unit #5, Tyngsboro, MA, 01879, USA. elizabeth.nelson@mothersmilkisbest.com., Kim JH; Perinatal Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Perrin MT; Department of Nutrition, University of North Carolina Greensboro, Greensboro, NC, 27412, USA., Dyer R; Analytical Core for Metabolomics and Nutrition, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada., Elango R; Analytical Core for Metabolomics and Nutrition, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada.; Department of Pediatrics, University of British Columbia, Vancouver, BC, V6H, 3V4, Canada., Bode L; Bode Lab, Department of Pediatrics, School of Medicine, University of California, San Diego, San Diego, CA, 92093, USA., Dallas DC; Dallas Lab, Nutrition Program, College of Health, Oregon State University, Corvallis, OR, 97331, USA., Lueangsakulthai J; Dallas Lab, Nutrition Program, College of Health, Oregon State University, Corvallis, OR, 97331, USA., Briere CE; Briere Lab, Elaine Marieb College of Nursing, University of Massachusetts Amherst, Amherst, MA, 01003, USA.; Institute for Nursing Research and Evidence-Based Practice, Connecticut Children's, Hartford, CT, 06106, US., Taylor SN; Division of Neonatology, Yale School of Medicine, New Haven, CT, 06520, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Nov; Vol. 44 (11), pp. 1575-1583. Date of Electronic Publication: 2024 May 17.
DOI: 10.1038/s41372-024-01988-2
Abstrakt: Objective: Preterm infants need enrichment of human milk (HM) for optimal growth. This study evaluated a novel, point-of-care human milk concentration (HMC) process for water removal from fresh HM samples by passive osmotic concentration.
Study Design: Nineteen fresh HM samples were concentrated by incubation with the HMC devices for 3 h at 4 °C. Pre- and post-concentration HM samples were compared by HM properties for: pH, osmolality, macronutrients, enzyme activity, bioactive, and total cell viability.
Results: Passive osmotic concentration reduced HM volume by an average of 16.3% ± 3.8% without a significant effect on pH or cell viability. Ten of the 41 HM components did not differ significantly (p > 0.05) between pre- and post-concentration samples. Twenty-three increased within the expected range by volume reduction. Six increased more than expected, two less than expected, and none decreased significantly.
Conclusion: Passive osmotic concentration of fresh HM can concentrate HM components by selective removal of water. HM osmolality and pH remained within neonatal feeding parameters.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: