Coinfection of a yaws patient with two closely related Treponema pallidum subsp. pertenue strains: A rare event with potential evolutionary implications.

Autor: Medappa M; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Pospíšilová P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic., John LN; Faculty of Medicine, University of Barcelona, Barcelona, Spain; National Department of Health, Aopi Centre, Port Moresby, Papua New Guinea., González-Beiras C; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Fight Infectious Diseases Foundation, Hospital Universitari Germans Traís i Pujol, Badalona, Spain; Universitat Autónoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallés), Spain., Mitjà O; Skin Neglected Tropical Diseases and Sexually Transmitted Infections section, Fight Infectious Diseases Foundation, Hospital Universitari Germans Traís i Pujol, Badalona, Spain; Universitat Autónoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallés), Spain., Šmajs D; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: dsmajs@med.muni.cz.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2024 Aug; Vol. 256, pp. 107254. Date of Electronic Publication: 2024 May 16.
DOI: 10.1016/j.actatropica.2024.107254
Abstrakt: The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, J E 11, and T E 13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely T E 13 and J E 11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or inter-subspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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