Not feeling the heat? Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.

Autor: Osorio M J; School of Biological Sciences, University of Aberdeen, AB24 2TZ, Scotland, UK; Institute of Neurobiology, University of Lübeck, 23562, Lübeck, Germany., Mitchell SE; School of Biological Sciences, University of Aberdeen, AB24 2TZ, Scotland, UK., Hambly C; School of Biological Sciences, University of Aberdeen, AB24 2TZ, Scotland, UK., Allison DB; Indiana University School of Public Health - Bloomington, Indiana, 47405, USA., Speakman JR; School of Biological Sciences, University of Aberdeen, AB24 2TZ, Scotland, UK; Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; China Medical University, Shenyang, Liaoning, China. Electronic address: j.speakman@abdn.ac.uk.
Jazyk: angličtina
Zdroj: Appetite [Appetite] 2024 Sep 01; Vol. 200, pp. 107421. Date of Electronic Publication: 2024 May 15.
DOI: 10.1016/j.appet.2024.107421
Abstrakt: Dietary protein modulates food intake (FI) via unclear mechanism(s). One possibility is that higher protein leads to greater post-ingestive heat production (Specific dynamic action: SDA) leading to earlier meal termination (increased satiation), and inhibition of further intake (increased satiety). The influence of dietary protein on feeding behaviour in C57BL/6J mice was tested using an automated FI monitoring system (BioDAQ), simultaneous to body temperature (T b ). Total FI, inter meal intervals (IMI, satiety) and meal size (MS, satiation) were related to changes in T b after consuming low (5%, LP), moderate (15%, MP) and high (30%, HP) protein diets. Diets were tested over three conditions: 1) room temperature (RT, 21 ± 1 °C), 2) room temperature and running wheels (RTRW) and 3) low temperature (10 °C) and running wheels (LTRW). The differences between diets and conditions were also compared using mixed models. Mice housed at RT fed HP diet, reduced total FI compared with LP and MP due to earlier meal termination (satiation effect). FI was lowered in RTRW conditions with no differences between diets. FI significantly increased under LTRW conditions for all diets, with protein content leading to earlier meal termination (satiation) but not the intervals between feeding bouts (satiety). T b fell immediately after feeding in all conditions. Despite a reduction in total FI in mice fed HP, mediated via increased satiation, this effect was not linked to increased T b during meals. We conclude effects of dietary protein on intake are not mediated via SDA and T b .
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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