Landscape of HER2-low breast cancer: Insights from a six-year study on prevalence and clinicopathological characteristics.

Autor: Khalil MA; Department of Hematology & Oncology, Saint Joseph University, Beirut, Lebanon. Electronic address: michel.aboukhalil1@net.usj.edu.lb., Habibian L; Department of Hematology & Oncology, Saint Joseph University, Beirut, Lebanon., Martin C; Department of Hematology & Oncology, Saint Joseph University, Beirut, Lebanon., Semaan K; Department of Hematology & Oncology, Saint Joseph University, Beirut, Lebanon., Khaddage A; Department of Pathology, Saint Joseph University, Beirut, Lebanon., El Kassis N; Department of Pathology, Saint Joseph University, Beirut, Lebanon., Kesserouani C; Department of Pathology, Saint Joseph University, Beirut, Lebanon., Kourie HR; Department of Hematology & Oncology, Saint Joseph University, Beirut, Lebanon., Atallah D; Department of Gynecology, Saint Joseph University, Beirut, Lebanon.
Jazyk: angličtina
Zdroj: Annals of diagnostic pathology [Ann Diagn Pathol] 2024 Oct; Vol. 72, pp. 152326. Date of Electronic Publication: 2024 May 12.
DOI: 10.1016/j.anndiagpath.2024.152326
Abstrakt: Human epidermal growth factor receptor 2 (HER2)-low breast cancer has emerged as a subtype of breast cancer, defined by HER2 1+/2+ in immunohistochemistry (IHC) and absence of ERBB2 gene amplification on fluorescence in situ hybridization (FISH). Recent trials showed marked response of HER2-low breast cancer to novel anti-HER2 antibody-drug-conjugates. Data on characteristics of HER2-low breast cancer subtype is limited. Real-world data from the Anatomic Pathology Department of Hotel-Dieu de France, spanning 2017-2023, was retrospectively collected. HER2-positive patients were excluded to compare HER2-low to HER2-zero breast cancer subtypes. Clinicopathological characteristics between the groups were compared using a Chi-Squared test. Out of 1195 patients, we observed 341 (28.5 %) HER2-low breast cancers cases. HER2-positive breast cancer cases (n = 178; 14.9 %) were excluded. There was no significant difference in age and sex between HER2-low and HER2-zero group (p = 0.33 and 0.79, respectively). HER2-low breast cancer was associated with positive estrogen receptor status and positive progesterone receptor status (p < 0.001 and p = 0.01, respectively). Ductal adenocarcinomas were more commonly observed in HER2-low group (p < 0.001). When stratified by hormone (HR) status, 87.4 % of patients had HR-positive status and 12.6 % were HR-negative. Among the HR-negative group, HER2-low tumors tended to show lower proliferation index compared to HER2-zero tumors (25%vs.10 %, p = 0.04). This study showed that HER2-low is distinct from HER2-zero and is common among patients with breast cancer. Clinicopathological features such as histological type differ between HER2-zero and HER2-low breast cancer. Within HR-negative breast cancer, those with low HER2 expression exhibit a less aggressive profile compared to HER2-zero tumors.
Competing Interests: Declaration of competing interest No conflict of interest to disclose.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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