Radiating blood flow signal: A new ultrasound feature of thyroid carcinoma.

Autor: Huang SS; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Yang Z; Department of Pathology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China., Li B; Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Jiang ZH; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Tan Y; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Hao DD; Department of Medical Ultrasonics, Shenzhen Bao'an District Songgang People's Hospital, Shenzhen, Guangdong, China., Chen CQ; Department of Medical Ultrasonics, Bao'an Central Hospital, Shenzhen, Guangdong, China., Wang YW; Department of Medical Ultrasonics, Guangzhou Concord Cancer Center, Guangzhou, China., Liang JY; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Pan FS; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Liu YH; Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Xie XY; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Zhu YF; Department of Thyroid Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address: zhuyifan@mail.sysu.edu.cn., Wang Z; Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address: wangzhu@mail.sysu.edu.cn.
Jazyk: angličtina
Zdroj: European journal of radiology [Eur J Radiol] 2024 Jul; Vol. 176, pp. 111502. Date of Electronic Publication: 2024 May 13.
DOI: 10.1016/j.ejrad.2024.111502
Abstrakt: Objective: To summary radiating blood flow signals and evaluate their diagnostic value in differentiating benign and malignant thyroid nodules.
Materials and Methods: We retrospectively recruited consecutive patients undergoing US at 4 hospitals from 2018 to 2022. In a training dataset, the correlations of US features with malignant thyroid nodules were assessed by multivariate logistic analysis. Multivariate logistic regression models involving the ACR TI-RADS score, radiating blood flow signals and their combination were built and validated internally and externally. The AUC with 95% asymptotic normal confidence interval as well as sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) with 95% exact binomial confidence intervals were calculated.
Results: Among 2475 patients (1818 women, age: 42.47 ± 11.57; 657 men, age: 42.16 ± 11.69), there were 3187 nodules (2342 malignant nodules and 845 benign nodules). Radiating blood flow signals were an independent risk factor for diagnosing thyroid carcinoma. In the training set, the AUC of the model using the combination of radiating blood flow signals and the ACR TI-RADS score (0.95 95 % CI: [0.94, 0.97]; P < 0.001) was significantly higher than that of the ACR TI-RADS model (0.91 [0.89, 0.93]). In the two internal validation sets and the external validation set, the AUCs of the combination model were 0.97 [0.96, 0.98], 0.92 [0.88, 0.96], and 0.91 [0.86, 0.95], respectively, and were all significantly higher than that of the ACR TI-RADS score (0.92 [0.90, 0.95], 0.86 [0.81, 0.91], 0.84 [0.79, 0.89]; P < 0.001).
Conclusion: Radiating blood flow is a new US feature of thyroid carcinomas that can significantly improve the diagnostic performance vs. the ACR TI-RADS score.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: