Respiratory Syncytial Virus and Influenza Infections in Children in Ulaanbaatar, Mongolia, 2015-2021.

Autor: Do LAH; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Tsedenbal N; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Khishigmunkh C; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Tserendulam B; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Altanbumba L; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Luvsantseren D; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Ulziibayar M; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Suuri B; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Narangerel D; National Center for Communicable Diseases, Ministry of Health, Ulaanbaatar, Mongolia., Tsolmon B; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia.; Medical Department, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia., Demberelsuren S; Expanded Program on Immunization, World Health Organization, Ulaanbaatar, Mongolia., Pell CL; Translational Microbiology Group, Murdoch Children's Research Institute, Melbourne, Australia., Manna S; Translational Microbiology Group, Murdoch Children's Research Institute, Melbourne, Australia., Satzke C; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; Translational Microbiology Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria, Australia., Nguyen C; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Mungun T; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., von Mollendorf C; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia., Badarch D; Virology Department, National Center of Communicable Diseases, Ulaanbaatar, Mongolia., Mulholland K; New Vaccines Group, Murdoch Children's Research Institute, Melbourne, Australia.; Department of Paediatrics, The University of Melbourne, Parkville, Australia.; Infectious Disease Epidemiology & International Health, London School of Hygiene and Tropical Medicine, London, UK.
Jazyk: angličtina
Zdroj: Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2024 May; Vol. 18 (5), pp. e13303.
DOI: 10.1111/irv.13303
Abstrakt: Background: Data available for RSV and influenza infections among children < 2 years in Mongolia are limited. We present data from four districts of Ulaanbaatar from April 2015 to June 2021.
Methods: This study was nested in an enhanced surveillance project evaluating pneumococcal conjugate vaccine (PCV13) impact on the incidence of hospitalized lower respiratory tract infections (LRTIs). Our study was restricted to children aged < 2 years with arterial O 2 saturation < 93% and children with radiological pneumonia. Nasopharyngeal (NP) swabs collected at admission were tested for RSV and influenza using qRT-PCR. NP swabs of all patients with radiological pneumonia and of a subset of randomly selected NP swabs were tested for S. pneumoniae (S.p.) by qPCR and for serotypes by culture and DNA microarray.
Results: Among 5705 patients, 2113 (37.0%) and 386 (6.8%) had RSV and influenza infections, respectively. Children aged 2-6 months had a higher percentage of very severe RSV infection compared to those older than 6 months (42.2% versus 31.4%, p-value Fisher's exact = 0.001). S.p. carriage was detected in 1073/2281 (47.0%) patients. Among S.p. carriage cases, 363/1073 (33.8%) had S.p. and RSV codetection, and 82/1073 (7.6%) had S.p. and influenza codetection. S.p. codetection with RSV/influenza was not associated with more severe LRTIs, compared to only RSV/influenza cases.
Conclusion: In Mongolia, RSV is an important pathogen causing more severe LRTI in children under 6 months of age. Codetection of RSV or influenza virus and S.p. was not associated with increased severity.
(© 2024 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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