Recreational nitrous oxide and thrombotic events: a case series.

Autor:	Patyjewicz M; Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre of Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Mair D; Royal London Hospital, Barts Health NHS Trust, London, UK.; Queen Mary University of London, London, UK., Zaloum SA; Royal London Hospital, Barts Health NHS Trust, London, UK.; Queen Mary University of London, London, UK., Onen B; Royal London Hospital, Barts Health NHS Trust, London, UK., Walton J; Royal London Hospital, Barts Health NHS Trust, London, UK., Dobson R; Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre of Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Joerres C; Royal London Hospital, Barts Health NHS Trust, London, UK., Shah AM; Royal London Hospital, Barts Health NHS Trust, London, UK., MacCallum P; Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre of Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Massey TH; Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.; UK-Dementia Research Institute, Cardiff University, Cardiff, UK., Bariana T; Royal London Hospital, Barts Health NHS Trust, London, UK., White V; Royal London Hospital, Barts Health NHS Trust, London, UK., De Freitas SA; Royal London Hospital, Barts Health NHS Trust, London, UK., Noyce A; Royal London Hospital, Barts Health NHS Trust, London, UK.; Centre of Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Jazyk:	angličtina
Zdroj:	BMJ neurology open [BMJ Neurol Open] 2024 May 15; Vol. 6 (1), pp. e000619. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
DOI:	10.1136/bmjno-2023-000619
Abstrakt:	Background: The study aimed to elucidate the prevalence of nitrous oxide (N2O) usage in patients with unexplained venous thromboembolism (VTE), highlighting the potential association with hyperhomocysteinaemia (HHcy). Methods: We conducted a retrospective study at the Royal London Hospital, examining cases of N2O-related VTE from March to August 2023. Among 50 patients identified, four (8%) had recent unprovoked VTE. Patient data were collected based on N2O ambulatory emergency care pathway admissions. Results: Among the 50 patients identified, four (8%) had recent or concurrent VTE. Three were male (75%), with an ethnic distribution of 50% Asian or Asian British and 50% Black or Black British. Patients were distributed across quintiles of the index of multiple deprivation. All had actual or functional vitamin B12 deficiency. Discussion: The association between N2O use and VTE requires further investigation, though a plausible mechanism involving HHcy has been proposed. Clinicians should be vigilant for VTE in N2O users, especially those presenting with unexplained symptoms. VTE prophylaxis may be worth considering, particularly if continued exposure to nitrous oxide is anticipated. Conclusion: N2O misuse may increase the risk of VTE, warranting attention from healthcare providers. Further research is needed to elucidate this association and inform preventive strategies. Public awareness about the risks of N2O remains essential. Competing Interests: Competing interests: AN reports grants from the Queen Mary Impact Fund and Tower Hamlets Council related to nitrous oxide educational programmes and clinical service development. DM leads the educational campaign N2O: Know the Risks. All other authors declare no competing interests. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu