The Role of Aryl Hydrocarbon Receptor in Bone Biology.

Autor: Vyavahare S; Department of Medicine, Augusta University, Augusta, GA, USA., Ahluwalia P; Department of Pathology, Augusta University, Augusta, GA, USA., Gupta SK; Department of Medicine, Augusta University, Augusta, GA, USA., Kolhe R; Department of Pathology, Augusta University, Augusta, GA, USA., Hill WD; Department of Pathology, Medical University of South Carolina, Charleston, SC, USA., Hamrick M; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.; Center for Healthy Aging, Augusta University, Augusta, GA, USA., Isales CM; Department of Medicine, Augusta University, Augusta, GA, USA.; Center for Healthy Aging, Augusta University, Augusta, GA, USA., Fulzele S; Department of Medicine, Augusta University, Augusta, GA, USA.; Department of Cell Biology and Anatomy, Augusta University, Augusta, GA, USA.; Center for Healthy Aging, Augusta University, Augusta, GA, USA.
Jazyk: angličtina
Zdroj: International journal of tryptophan research : IJTR [Int J Tryptophan Res] 2024 May 15; Vol. 17, pp. 11786469241246674. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
DOI: 10.1177/11786469241246674
Abstrakt: Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is crucial in maintaining the skeletal system. Our study focuses on encapsulating the role of AhR in bone biology and identifying novel signaling pathways in musculoskeletal pathologies using the GEO dataset. The GEO2R analysis identified 8 genes (CYP1C1, SULT6B1, CYB5A, EDN1, CXCR4B, CTGFA, TIPARP, and CXXC5A) involved in the AhR pathway, which play a pivotal role in bone remodeling. The AhR knockout in hematopoietic stem cells showed alteration in several novel bone-related transcriptomes (eg, Defb14, ZNF 51, and Chrm5). Gene Ontology Enrichment Analysis demonstrated 54 different biological processes associated with bone homeostasis. Mainly, these processes include bone morphogenesis, bone development, bone trabeculae formation, bone resorption, bone maturation, bone mineralization, and bone marrow development. Employing Functional Annotation and Clustering through DAVID, we further uncovered the involvement of the xenobiotic metabolic process, p450 pathway, oxidation-reduction, and nitric oxide biosynthesis process in the AhR signaling pathway. The conflicting evidence of current research of AhR signaling on bone (positive and negative effects) homeostasis may be due to variations in ligand binding affinity, binding sites, half-life, chemical structure, and other unknown factors. In summary, our study provides a comprehensive understanding of the underlying mechanisms of the AhR pathway in bone biology.
Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
(© The Author(s) 2024.)
Databáze: MEDLINE
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