Low-intensity repetitive transcranial magnetic stimulation is safe and well tolerated by people living with MS - outcomes of the phase I randomised controlled trial (TAURUS).
| Autor: | Nguyen PT, Zarghami A, Makowiecki K, Stevens N, Ezegbe C; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Kyle K; Sydney Neuroimaging Analysis Centre (SNAC), Sydney, New South Wales, Australia., Wang C; Sydney Neuroimaging Analysis Centre (SNAC), Sydney, New South Wales, Australia., Ly L; Sydney Neuroimaging Analysis Centre (SNAC), Sydney, New South Wales, Australia., De La Rue K; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Hinder MR; School of Psychological Sciences, University of Tasmania, Hobart, Tasmania, Australia., Johnson L; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Rodger J; School of Biological Sciences, The University of Western Australia, Crawley, Western Australia, Australia., Cooper S; Royal Hobart Hospital, Hobart, Tasmania, Australia., Cullen CL; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Barnett M; Sydney Neuroimaging Analysis Centre (SNAC), Sydney, New South Wales, Australia., Young KM; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Taylor BV; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | Multiple sclerosis journal - experimental, translational and clinical [Mult Scler J Exp Transl Clin] 2024 May 15; Vol. 10 (2), pp. 20552173241252571. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| DOI: | 10.1177/20552173241252571 |
| Abstrakt: | Background: Low-intensity repetitive transcranial magnetic stimulation (rTMS), delivered as a daily intermittent theta burst stimulation (iTBS) for four consecutive weeks, increased the number of new oligodendrocytes in the adult mouse brain. Therefore, rTMS holds potential as a remyelinating intervention for people with multiple sclerosis (MS). Objective: Primarily to determine the safety and tolerability of our rTMS protocol in people with MS. Secondary objectives include feasibility, blinding and an exploration of changes in magnetic resonance imaging (MRI) metrics, patient-reported outcome measures (PROMs) and cognitive or motor performance. Methods: A randomised (2:1), placebo controlled, single blind, parallel group, phase 1 trial of 20 rTMS sessions (600 iTBS pulses per hemisphere; 25% maximum stimulator output), delivered over 4-5 weeks. Twenty participants were randomly assigned to 'sham' ( n = 7) or active rTMS ( n = 13), with the coil positioned at 90° or 0°, respectively. Results: Five adverse events (AEs) including one serious AE reported. None were related to treatment. Protocol compliance was high (85%) and blinding successful. Within participant MRI metrics, PROMs and cognitive or motor performance were unchanged over time. Conclusion: Twenty sessions of rTMS is safe and well tolerated in a small group of people with MS. The study protocol and procedures are feasible. Improvement of sham is warranted before further investigating safety and efficacy. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s), 2024.) |
| Databáze: | MEDLINE |
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