| Autor: |
Gold MR, Miller CL, Mishell RI |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 1985 Sep; Vol. 49 (3), pp. 731-41. |
| DOI: |
10.1128/iai.49.3.731-741.1985 |
| Abstrakt: |
Soluble non-cross-linked peptidoglycan polymers are released by gram-positive bacteria when beta-lactam antibiotics are administered to humans. In this report, we show that this type of peptidoglycan can stimulate monocyte-macrophage functions that cause inflammation. Non-cross-linked peptidoglycan polymers from penicillin-treated Streptococcus faecium were purified and shown to stimulate the production of interleukin 1 by human monocytes and of colony-stimulating factors by a murine macrophage cell line. In addition, the release of plasminogen activator by human monocytes was inhibited by the soluble peptidoglycan. These in vitro results suggest that prolonged treatment with beta-lactam antibiotics, by causing the production of soluble peptidoglycan, may result in interleukin 1-mediated inflammatory reactions, excessive production of monocytes and granulocytes, and increased fibrin deposition. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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