Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke.
Autor: | Sikora M; European Centre for Bioinformatics and Genomics, Institute of Bioorganic Chemistry, 61-704, Poznań, Poland., Bretes E; Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland., Perła-Kaján J; Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland., Utyro O; Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland., Borowczyk K; Faculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland., Piechocka J; Faculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland., Głowacki R; Faculty of Chemistry, Department of Environmental Chemistry, University of Łódź, 90-236, Łódź, Poland., Wojtasz I; Medicover, 61-131, Poznań, Poland., Kaźmierski R; Department of Neurology, Collegium Medicum, University of Zielona Góra, 65-046, Zielona Góra, Poland.; Department of Neurology, Poznań University of Medical Sciences, 60-355, Poznań, Poland., Jakubowski H; Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, 60-632, Poznań, Poland. jakubows@rutgers.edu.; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, International Center for Public Health, 225 Warren Street, Newark, NJ, 07103, USA. jakubows@rutgers.edu. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2024 May 16; Vol. 14 (1), pp. 11222. Date of Electronic Publication: 2024 May 16. |
DOI: | 10.1038/s41598-024-60706-2 |
Abstrakt: | Homocysteine (Hcy) and Hcy-thiolactone (HTL) affect fibrin clot properties and are linked to cardiovascular disease. Factors that influence fibrin clot properties and stroke are not fully understood. To study sulfur-containing amino acid metabolites, fibrin clot lysis time (CLT) and maximum absorbance (Abs (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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