Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea.

Autor: Akoi Boré J; Ministère de la Santé et de l'hygiène publique, Conakry, Guinea., Timothy JWS; Faulty of Infectious & Tropical Diseases, London School of Hygiene Tropical Medicine, London, UK., Tipton T; Centre for Human Genetics & Pandemic Sciences Inst, University of Oxford, Oxford, UK., Kekoura I; Ministère de la Santé et de l'hygiène publique, Conakry, Guinea., Hall Y; UK Health Security Agency, Porton Down, UK., Hood G; Centre for Human Genetics & Pandemic Sciences Inst, University of Oxford, Oxford, UK., Longet S; Centre for Human Genetics & Pandemic Sciences Inst, University of Oxford, Oxford, UK., Fornace K; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore., Lucien MS; Ministère de la Santé et de l'hygiène publique, Conakry, Guinea., Fehling SK; Institute of Virology, Philipps University, Marburg, Germany., Koivogui BK; Ministère de la Santé et de l'hygiène publique, Conakry, Guinea., Coggins SA; Department of Microbiology and Immunology, Uniformed Services University, MD, USA., Laing ED; Department of Microbiology and Immunology, Uniformed Services University, MD, USA., Broder CC; Department of Microbiology and Immunology, Uniformed Services University, MD, USA., Magassouba NF; Ministère de la Santé et de l'hygiène publique, Conakry, Guinea., Strecker T; Institute of Virology, Philipps University, Marburg, Germany., Rossman J; School of Bioscience, University of Kent, Canterbury, UK., Konde K; Centre for Training and Research on Priority Diseases including Malaria in Guinea, Conakry, Guinea., Carroll MW; Centre for Human Genetics & Pandemic Sciences Inst, University of Oxford, Oxford, UK. Miles.Carroll@ndm.ox.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 16; Vol. 15 (1), pp. 4171. Date of Electronic Publication: 2024 May 16.
DOI: 10.1038/s41467-024-48587-5
Abstrakt: Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat hunters (n = 498) in Macenta Prefecture Guinea, adjacent to the index site of the 2013 EBOV-Makona spillover event. We identified distinct immune signatures (20/498, 4.0%) to multiple EBOV antigens (GP, NP, VP40) using stepwise ELISA and Western blot analysis and, live EBOV neutralisation (5/20; 25%). Using comparative serological data from PCR-confirmed survivors of the 2013-2016 EBOV outbreak, we demonstrated that most signatures (15/20) were not plausibly explained by prior EBOV-Makona exposure. Subsequent data-driven modelling of EBOV immunological outcomes to remote-sensing environmental data also revealed consistent associations with intact closed canopy forest. Together our findings suggest exposure to other closely related filoviruses prior to the 2013-2016 West Africa epidemic and highlight future surveillance priorities.
(© 2024. The Author(s).)
Databáze: MEDLINE
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