Characterization of Microwave Generator Energy and Ablation Volumes following Transarterial Embolization in an In Vivo Porcine Liver Model.

Autor: Sparks H; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California. Electronic address: HDSparks@mednet.ucla.edu., Rink JS; Department for Radiology and Nuclear Medicine, Mannheim University Medical Centre, Mannheim, Germany., Ramakrishnan A; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Sung K; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Ni J; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Lu DSK; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Raman SS; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Lee EW; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California., Chiang J; Department of Radiology, Ronald Reagan University of California, Los Angeles Medical Center, Los Angeles, California.
Jazyk: angličtina
Zdroj: Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2024 Aug; Vol. 35 (8), pp. 1227-1233. Date of Electronic Publication: 2024 May 14.
DOI: 10.1016/j.jvir.2024.05.005
Abstrakt: Purpose: To characterize the relationship between ablation zone volume (AZV) and microwave ablation (MWA) energy in an in vivo porcine liver model following arterial embolization.
Materials and Methods: With Institutional Animal Care and Use Committee (IACUC) approval, 11 female swine underwent either right (n = 5) or left (n = 6) hepatic artery embolization under fluoroscopic guidance. Subsequently, ultrasound (US)-guided MWA was performed in each liver segment (left lateral, left medial, right medial, and right lateral) at either 30 W (n = 4 lobes), 60 W (n = 4), 65 W (n = 20), 90 W (n = 8), 120 W (n = 4), or 140 W (n = 4) continuously for 5 minutes. Postprocedural volumetric segmentation was performed on standardized multiphase T1 magnetic resonance (MR) imaging sequences.
Results: Mean AZVs in embolized lobes (15.8 mL ± SD 10.6) were significantly larger than those in nonembolized lobes (11.2 mL ± SD 6.5, P < .01). MWA energy demonstrated significant positive linear correlation with both embolized (R 2  = 0.66, P < .01) and nonembolized (R 2  = 0.64, P < .01) lobes. The slope of the linear models corresponded to a 0.95 mL/kJ (SD ± 0.16) and 0.54 mL/kJ (SD ± 0.09) increase in ablation volume per applied kilojoule of energy (E) in embolized and nonembolized lobes, respectively. In the multivariate model, embolization status significantly modified the relationship between E and AZV as described by the following interaction term: 0.42∗E∗(embolization status) (P = .031).
Conclusions: Linear models demonstrated a near 1.8-fold increase in ratio of AZV per unit E, R(AZV:E), when applied to embolized lobes relative to nonembolized lobes. Absolute AZV differences between embolized and nonembolized lobes were greater at higher-power MWA.
(Published by Elsevier Inc.)
Databáze: MEDLINE
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