Relationship between EEG spectral power and dysglycemia with neurodevelopmental outcomes after neonatal encephalopathy.

Autor: Damien J; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Department of Psychology, University of Montreal, Montreal, QC, Canada. Electronic address: janie.damien@umontreal.ca., Vannasing P; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: pvannasing@gmail.com., Tremblay J; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: julie.tremblay2.hsj@ssss.gouv.qc.ca., Petitpas L; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Department of Psychology, University of Montreal, Montreal, QC, Canada. Electronic address: laurence.petitpas.hsj@ssss.gouv.qc.ca., Marandyuk B; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: bohdana.marandyuk.hsj@ssss.gouv.qc.ca., Balasingam T; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: thameya.balasingam@umontreal.ca., El Jalbout R; Department of Radiology, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: ramy.el-jalbout.med@ssss.gouv.qc.ca., Paquette N; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Department of Psychology, University of Montreal, Montreal, QC, Canada. Electronic address: natacha.paquette.hsj@ssss.gouv.qc.ca., Donofrio G; Department of Neurosciences Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Via Gerolamo Gaslini 5, 16147 Genoa, Italy; Service of Neurology, Department of Pediatrics, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: gianluca.donofrio.med@ssss.gouv.qc.ca., Birca A; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Service of Neurology, Department of Pediatrics, Sainte-Justine University Hospital Centre, Montreal, QC, Canada., Gallagher A; Neurodevelopmental Optical Imaging Laboratory (LION Lab), Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Department of Psychology, University of Montreal, Montreal, QC, Canada. Electronic address: anne.gallagher@umontreal.ca., Pinchefsky EF; Research Centre, Sainte-Justine University Hospital Centre, Montreal, QC, Canada; Service of Neurology, Department of Pediatrics, Sainte-Justine University Hospital Centre, Montreal, QC, Canada. Electronic address: elana.pinchefsky.med@ssss.gouv.qc.ca.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2024 Jul; Vol. 163, pp. 160-173. Date of Electronic Publication: 2024 Apr 06.
DOI: 10.1016/j.clinph.2024.03.029
Abstrakt: Objective: We investigated how electroencephalography (EEG) quantitative measures and dysglycemia relate to neurodevelopmental outcomes following neonatal encephalopathy (NE).
Methods: This retrospective study included 90 neonates with encephalopathy who received therapeutic hypothermia. EEG absolute spectral power was calculated during post-rewarming and 2-month follow-up. Measures of dysglycemia (hypoglycemia, hyperglycemia, and glycemic lability) and glucose variability were computed for the first 48 h of life. We evaluated the ability of EEG and glucose measures to predict neurodevelopmental outcomes at ≥ 18 months, using logistic regressions (with area under the receiver operating characteristic [AUROC] curves).
Results: The post-rewarming global delta power (average all electrodes), hyperglycemia and glycemic lability predicted moderate/severe neurodevelopmental outcome separately (AUROC = 0.8, 95%CI [0.7,0.9], p < .001) and even more so when combined (AUROC = 0.9, 95%CI [0.8,0.9], p < .001). After adjusting for NE severity and magnetic resonance imaging (MRI) brain injury, only global delta power remained significantly associated with moderate/severe neurodevelopmental outcome (odds ratio [OR] = 0.9, 95%CI [0.8,1.0], p = .04), gross motor delay (OR = 0.9, 95%CI [0.8,1.0], p = .04), global developmental delay (OR = 0.9, 95%CI [0.8,1.0], p = .04), and auditory deficits (OR = 0.9, 95%CI [0.8,1.0], p = .03).
Conclusions: In NE, global delta power post-rewarming was predictive of outcomes at ≥ 18 months.
Significance: EEG markers post-rewarming can aid prediction of neurodevelopmental outcomes following NE.
(Crown Copyright © 2024. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: