Synaptic Protein Loss in Extracellular Vesicles Reflects Brain and Retinal Atrophy in People With Multiple Sclerosis.

Autor:	Ladakis DC; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Vreones M; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Blommer J; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Harrison KL; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Smith MD; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Vasileiou ES; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Moussa H; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Ahmadi G; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Ezzedin O; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., DuVal AL; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Dewey BE; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Prince JL; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Fitzgerald KC; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Sotirchos ES; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Saidha S; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Calabresi PA; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Kapogiannis D; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD., Bhargava P; From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
Jazyk:	angličtina
Zdroj:	Neurology(R) neuroimmunology & neuroinflammation [Neurol Neuroimmunol Neuroinflamm] 2024 Jul; Vol. 11 (4), pp. e200257. Date of Electronic Publication: 2024 May 16.
DOI:	10.1212/NXI.0000000000200257
Abstrakt:	Objectives: To assess whether the rate of change in synaptic proteins isolated from neuronally enriched extracellular vesicles (NEVs) is associated with brain and retinal atrophy in people with multiple sclerosis (MS). Methods: People with MS were followed with serial blood draws, MRI (MRI), and optical coherence tomography (OCT) scans. NEVs were immunocaptured from plasma, and synaptopodin and synaptophysin proteins were measured using ELISA. Subject-specific rates of change in synaptic proteins, as well as brain and retinal atrophy, were determined and correlated. Results: A total of 50 people with MS were included, 46 of whom had MRI and 45 had OCT serially. The rate of change in NEV synaptopodin was associated with whole brain (rho = 0.31; p = 0.04), cortical gray matter (rho = 0.34; p = 0.03), peripapillary retinal nerve fiber layer (rho = 0.37; p = 0.01), and ganglion cell/inner plexiform layer (rho = 0.41; p = 0.006) atrophy. The rate of change in NEV synaptophysin was also correlated with whole brain (rho = 0.31; p = 0.04) and cortical gray matter (rho = 0.31; p = 0.049) atrophy. Discussion: NEV-derived synaptic proteins likely reflect neurodegeneration and may provide additional circulating biomarkers for disease progression in MS.
Databáze:	MEDLINE
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