A longitudinal evaluation of personalized intrinsic network topography and cognitive decline in Parkinson's disease.

Autor: Li R; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Pozorski V; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Dabbs K; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Haebig M; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Cox CR; Department of Psychology, Louisiana State University, Baton Rouge, Louisiana, USA., Pletcher C; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Wey A; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Barzgari A; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Theisen F; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Okonkwo O; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer Disease Research Center, Madison, Wisconsin, USA., Gallagher CL; William S. Middleton V.A. Hospital, Madison, Wisconsin, USA.; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; Wisconsin Alzheimer Disease Research Center, Madison, Wisconsin, USA.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2024 Jul; Vol. 60 (1), pp. 3795-3811. Date of Electronic Publication: 2024 May 16.
DOI: 10.1111/ejn.16380
Abstrakt: Resting state functional magnetic resonance imaging (R-fMRI) offers insight into how synchrony within and between brain networks is altered in disease states. Individual and disease-related variability in intrinsic connectivity networks may influence our interpretation of R-fMRI data. We used a personalized approach designed to account for individual variation in the spatial location of correlation maxima to evaluate R-fMRI differences between Parkinson's disease (PD) patients who showed cognitive decline, those who remained cognitively stable and cognitively stable controls. We compared fMRI data from these participant groups, studied at baseline and 18 months later, using both network-based statistics (NBS) and calculations of mean inter- and intra-network connectivity within pre-defined functional networks. The NBS analysis showed that PD participants who remained cognitively stable showed exclusively (at baseline) or predominantly (at follow-up) increased intra-network connectivity, whereas decliners showed exclusively reduced intra-network and inter- (ventral attention and default mode) connectivity, in comparison with the control group. Evaluation of mean connectivity between all regions of interest (ROIs) within a priori networks showed that decliners had consistently reduced inter-network connectivity for ventral attention, somatomotor, visual and striatal networks and reduced intra-network connectivity for ventral attention network to striatum and cerebellum. These findings suggest that specific functional connectivity covariance patterns differentiate PD cognitive subtypes and may predict cognitive decline. Further, increased intra and inter-network synchrony may support cognitive function in the face of PD-related network disruptions.
(© 2024 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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