Vaccinomics and adversomics: key elements for a personalized vaccinology.

Autor: Laganà A; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.; Istituto Clinico Polispecialistico C.O.T., Cure Ortopediche Traumatologiche S.P.A., Messina, Italy., Visalli G; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy., Di Pietro A; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy., Facciolà A; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Jazyk: angličtina
Zdroj: Clinical and experimental vaccine research [Clin Exp Vaccine Res] 2024 Apr; Vol. 13 (2), pp. 105-120. Date of Electronic Publication: 2024 Apr 30.
DOI: 10.7774/cevr.2024.13.2.105
Abstrakt: Vaccines are one of the most important and effective tools in the prevention of infectious diseases and research about all the aspects of vaccinology are essential to increase the number of available vaccines more and more safe and effective. Despite the unquestionable value of vaccinations, vaccine hesitancy has spread worldwide compromising the success of vaccinations. Currently, the main purpose of vaccination campaigns is the immunization of whole populations with the same vaccine formulations and schedules for all individuals. A personalized vaccinology approach could improve modern vaccinology counteracting vaccine hesitancy and giving great benefits for human health. This ambitious purpose would be possible by facing and deepening the areas of vaccinomics and adversomics, two innovative areas of study investigating the role of a series of variables able to influence the immune response to vaccinations and the development of serious side effects, respectively. We reviewed the recent scientific knowledge about these innovative sciences focusing on genetic and non-genetic basis involved in the individual response to vaccines in terms of both immune response and side effects.
Competing Interests: No potential conflict of interest relevant to this article was reported.
(© Korean Vaccine Society.)
Databáze: MEDLINE
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