Association between dopamine receptor D2 Taq IA gene polymorphism (rs1800497) and personality traits.
| Autor: | Olasore HSA; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria., Oyedeji TA; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria., Faleti JO; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria., Ogundele OI; Faculty of Basic Medical Sciences, Department of Biochemistry, College of Medicine of the University of Lagos, Idi Araba, Lagos, Nigeria., Olashore AA; Faculty of Medicine, Department of Psychiatry, University of Botswana, Gaborone, Botswana. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | SAGE open medicine [SAGE Open Med] 2024 May 14; Vol. 12, pp. 20503121241241922. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024). |
| DOI: | 10.1177/20503121241241922 |
| Abstrakt: | Objective: This study aimed to find a potential association between the DRD2 Taq 1A gene polymorphism (rs1800497 C32806T) and personality traits. Methods: In all, 249 youths were recruited for this study. The Short-form Revised Eysenck Personality Questionnaire was administered to assess personality traits. The participants were genotyped for the DRD2 Taq 1A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism method. Statistical analysis was carried out to find a possible association between the genotypes and aspects of personality traits assessed. Results: The frequencies of the A1 and A2 alleles in our sampled population were 215 (43.2%) and 283 (56.8%), while the frequencies of A1A1, A1A2, and A2A2 were 67 (26.9%), 81 (32.5%), and 101 (40.6%), respectively. The study population was not in Hardy-Weinberg equilibrium ( χ 2 = 17.64, p < 0.001). The A2 allele was significantly associated with extraversion. Although this allele was also associated with neuroticism, psychoticism, and lie, the association was not significant. Conclusion: The A2 allele of the DRD2 Taq 1A polymorphism was found to be more associated with extraversion, as measured by the Short-form Revised Eysenck Personality Questionnaire. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2024.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|