Reduction in tumor grade and Ki-67 in postmenopausal patient with node-positive invasive ductal carcinoma following combination hormone replacement therapy cessation: a case report.

Autor:	King CA; Department of Surgery, Division of Breast Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Masanam MK; Department of Surgery, Division of Breast Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Maini AS; Department of Surgery, Division of Breast Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Merritt CM; Department of Surgery, Division of Breast Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Fan KL; Department of Plastic Surgery, MedStar Georgetown University Hospital, Washington, DC, USA., Greenwalt IT; Department of Surgery, Division of Breast Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.
Jazyk:	angličtina
Zdroj:	Translational breast cancer research : a journal focusing on translational research in breast cancer [Transl Breast Cancer Res] 2022 Jul 30; Vol. 3, pp. 29. Date of Electronic Publication: 2022 Jul 30 (Print Publication: 2022).
DOI:	10.21037/tbcr-22-26
Abstrakt:	Background: While praised for its benefits in treating symptoms related to menopausal changes, hormone replacement therapy (HRT) has been associated with an increased risk for hormone-dependent cancer development, particularly endometrial and breast. Few studies have elucidated the relationship between HRT cessation and hormone receptor-positive breast cancer proliferation. We report herein, to the best of our knowledge, the first case of 28.6% relative reduction in proliferation index marker Ki-67 in node-positive hormone receptor-positive breast cancer following HRT cessation. Case Description: We report an unusual case of a 64-year-old female patient with longstanding HRT for fifteen years who underwent immediate discontinuation after diagnosis of poorly differentiated invasive ductal carcinoma. We observed a reduction in tumor grade from poorly differentiated at time of biopsy to moderately differentiated at time of surgery following cessation of HRT, as well as a reduction in the tumor proliferation index (Ki-67) from 70% to 50%. The patient has remained recurrence-free at the one-year mark postoperatively with continued follow-up. Conclusions: This case highlights potential clinical benefits associated with HRT discontinuation in the postmenopausal population with preexisting hormone-dependent cancers with high proliferation index, as well as the usefulness of Ki-67 in measuring response to aromatase inhibition in this subpopulation of patients. Keywords: Hormone replacement therapy (HRT); breast cancer; tumor grade; Ki-67; case report. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tbcr.amegroups.com/article/view/10.21037/tbcr-22-26/coif). The authors have no conflicts of interest to declare. (2022 Translational Breast Cancer Research. All rights reserved.)
Databáze:	MEDLINE
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