Retinal Pigment Epithelial Adenoma: Initial Treatment Outcomes following Episcleral Brachytherapy.

Autor:	Fayed AE; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt.; Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Swaify IY; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Khattab AM; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Macky TA; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Hassanein DH; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Salah SH; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Abdullatif AM; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Noureldine AM; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Fadel MR; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Helmy YAH; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Elnahry AG; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt.; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Meqdad YA; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt., Yesiltas YS; Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland, OH, USA.; Anatomic Pathology Cleveland Clinic, Cleveland, OH, USA., Singh AD; Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland, OH, USA.; Anatomic Pathology Cleveland Clinic, Cleveland, OH, USA., Hamza H; Department of Ophthalmology, Cairo University Ocular Oncology Service, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Ocular oncology and pathology [Ocul Oncol Pathol] 2024 Apr; Vol. 10 (1), pp. 9-14. Date of Electronic Publication: 2024 Jan 16.
DOI:	10.1159/000536127
Abstrakt:	Introduction: We aim to explore the safety and efficacy of episcleral brachytherapy as a primary management option for eyes with retinal pigment epithelial (RPE) adenoma. Methods: Retrospective chart review of the demographic, clinical, ancillary, and postoperative outcome data of patients with RPE adenoma in 2 tertiary referral centers. Tumor regression, final visual acuity, and complications were assessed. Results: Five patients (3 females and 2 males) were included. Four of the 5 eyes had peripheral and mid-peripheral lesions, while one tumor was juxtapapillary. Three eyes were treated with ruthenium-106 (100 Gray), and 2 received iodine-125 episcleral plaques (85 Gray). All eyes showed clinical and imaging-based evidence of regression. Four eyes had stable or improved visual acuity, while 1 eye exhibited one line loss of visual acuity due to radiation retinopathy. Local recurrence was not observed in any eye over a median follow-up of 24 (range 6-112) months. Conclusions: Episcleral brachytherapy is an effective management option for select cases of RPE adenoma that is capable of achieving tumor regression while maintaining favorable visual acuity. The initial safety profile of brachytherapy is good without significant vision-compromising complications. Competing Interests: All authors certify that they have no conflict of interest in the subject matter or materials discussed in this manuscript. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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