Current use of estrogen-containing oral contraceptives or hormone therapy and risk of COVID-19 infection and hospitalization: a population-based cohort study.

Autor:	Harrington LB; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States.; Department of Epidemiology, University of Washington, Seattle, WA 98195, United States.; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, United States., Powers JD; Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO 80011, United States., Bayliss EA; Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO 80011, United States.; Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO 80045, United States., Fortmann SP; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, United States.; Kaiser Permanente Center for Health Research, Portland, OR 97227, United States., Shortreed SM; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States.; Department of Biostatistics, University of Washington, Seattle, WA 98195, United States., Walker RL; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States., Floyd JS; Department of Epidemiology, University of Washington, Seattle, WA 98195, United States.; Department of Medicine, University of Washington, Seattle, WA 98195, United States., Kuntz J; Kaiser Permanente Center for Health Research, Portland, OR 97227, United States., Fuller S; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States., Alberston-Junkans L; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States., Lee MH; Kaiser Permanente Center for Health Research, Portland, OR 97227, United States., Temposky LA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States., Dublin S; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, United States.; Department of Epidemiology, University of Washington, Seattle, WA 98195, United States.; Department of Health Systems Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA 91101, United States.
Jazyk:	angličtina
Zdroj:	American journal of epidemiology [Am J Epidemiol] 2024 Oct 07; Vol. 193 (10), pp. 1417-1425.
DOI:	10.1093/aje/kwae066
Abstrakt:	The association between current use of oral contraceptives (OCs) among women younger than 50 years (n = 306 541), and hormone therapy (HT) among women aged 50 years or older (n = 323 203), and coronavirus 2019 (COVID-19) infection and hospitalization was evaluated in this population-based cohort. Current OC/HT use was recorded monthly using prescription dispensing data. COVID-19 infections were identified from March 2020 through February 2021. COVID-19 infections and hospitalizations were identified through diagnosis codes and laboratory tests. We used weighted generalized estimating equations models to estimate multivariable adjusted odds ratios (aORs) for COVID-19 infection associated with time-varying OC/HT use. Among women with COVID-19, logistic regression models were used to evaluate OC/HT use and COVID-19 hospitalization. Over 12 months, 11 727 (3.8%) women younger than 50 years and 8661 (2.7%) women aged 50 years or older experienced COVID-19 infections. There was no evidence of an association between OC use and infection (aOR = 1.05; 95% CI, 0.97-1.12). There was a modest association between HT use and infection (aOR = 1.19; 95% CI, 1.03-1.38). Women using OCs had a 39% lower risk of hospitalization (aOR = 0.61; 95% CI, 0.38-1.00), but there was no association of HT use with hospitalization (aOR = 0.89; 95% CI, 0.51-1.53). These findings do not suggest a meaningfully greater risk of COVID-19 infection associated with OC or HT use. OC use may be associated with lower COVID-19 hospitalization risk. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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