Cassava brown streak virus evolves with a nucleotide-substitution rate that is typical for the family Potyviridae.

Autor: Mbewe W; Department of Biological Sciences, Malawi University of Science and Technology, P. O. Box 5196, Limbe, Malawi. Electronic address: wmbewe@must.ac.mw., Mukasa S; School of Agriculture and Environmental Science, Department of Agricultural Production, P. O. Box 7062, Makerere University, Kampala, Uganda., Ochwo-Ssemakula M; School of Agriculture and Environmental Science, Department of Agricultural Production, P. O. Box 7062, Makerere University, Kampala, Uganda., Sseruwagi P; Mikocheni Agricultural Research Institute, P.O. Box 6226, Dar es Slaam, Tanzania., Tairo F; Mikocheni Agricultural Research Institute, P.O. Box 6226, Dar es Slaam, Tanzania., Ndunguru J; Mikocheni Agricultural Research Institute, P.O. Box 6226, Dar es Slaam, Tanzania., Duffy S; Department of Ecology, Evolution and Natural Resources, Rutgers University, New Brunswick, NJ 08901, United States. Electronic address: duffy@sebs.rutgers.edu.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2024 Aug; Vol. 346, pp. 199397. Date of Electronic Publication: 2024 May 22.
DOI: 10.1016/j.virusres.2024.199397
Abstrakt: The ipomoviruses (family Potyviridae) that cause cassava brown streak disease (cassava brown streak virus [CBSV] and Uganda cassava brown streak virus [UCBSV]) are damaging plant pathogens that affect the sustainability of cassava production in East and Central Africa. However, little is known about the rate at which the viruses evolve and when they emerged in Africa - which inform how easily these viruses can host shift and resist RNAi approaches for control. We present here the rates of evolution determined from the coat protein gene (CP) of CBSV (Temporal signal in a UCBSV dataset was not sufficient for comparable analysis). Our BEAST analysis estimated the CBSV CP evolves at a mean rate of 1.43 × 10 -3 nucleotide substitutions per site per year, with the most recent common ancestor of sampled CBSV isolates existing in 1944 (95% HPD, between years 1922 - 1963). We compared the published measured and estimated rates of evolution of CPs from ten families of plant viruses and showed that CBSV is an average-evolving potyvirid, but that members of Potyviridae evolve more quickly than members of Virgaviridae and the single representatives of Betaflexiviridae, Bunyaviridae, Caulimoviridae and Closteroviridae.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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