Paxbp1 is indispensable for the maintenance of peripheral CD4 T cell homeostasis.

Autor: Li W; Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China., Yang Y; Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China., Zhuo F; Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China., Liu S; Key Laboratory of Research and Utilization of Ethnomedicinal Plant Resources of Hunan Province, College of Biological and Food Engineering, Huaihua University, Huaihua, Hunan Province, China., Zhang K; Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China., Zhang W; Biomedical Research Institute, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, China.; Greater Bay Biomedical Innocenter, Shenzhen Bay Laboratory, Shenzhen, Guangdong Province, China., Huang C; Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China., Yu B; Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.; Shenzhen Key Laboratory for Translational Medicine of Dermatology, Shenzhen Peking University - The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China.
Jazyk: angličtina
Zdroj: Immunology [Immunology] 2024 Aug; Vol. 172 (4), pp. 641-652. Date of Electronic Publication: 2024 May 15.
DOI: 10.1111/imm.13802
Abstrakt: The size and condition of the peripheral CD4 T cell population determine the capacity of the immune response. Under homeostatic conditions, the size of the peripheral CD4 T cell population is maintained through turnover and survival. However, the underlying mechanisms remain inadequately understood. Here, we observed a significant decrease in the percentage of CD4 T cells in the periphery following the targeted deletion of the Paxbp1 gene in mouse T cells. In the absence of Paxbp1, naïve CD4 T cells displayed reduced surface interleukin-7 receptor levels and a decreased capacity to respond to survival signals mediated by interleukin-7. In addition, naïve CD4 T cells deficient in Paxbp1 demonstrated impaired T cell antigen receptor signalling, compromised cell cycle entry, decreased proliferation, and increased apoptosis following stimulation, all of which contributed to the reduction in the number of peripheral CD4 T cells. Therefore, our study highlights the indispensable role of Paxbp1 in maintaining peripheral CD4 T cell homeostasis.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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