Accelerative Solid-State Oxidation Behaviour of Amorphous and Partially Crystalline Venetoclax.

Autor: Afonso Urich JA; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria., Marko V; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria., Boehm K; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria., Werner B; Institute of Chemistry, University of Graz, Heinrichstr. 28, 8010, Graz, Austria., Zangger K; Institute of Chemistry, University of Graz, Heinrichstr. 28, 8010, Graz, Austria., Saraf I; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria., Paudel A; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria. amrit.paudel@rcpe.at.; Institute of Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010, Graz, Austria. amrit.paudel@rcpe.at., Kushwah V; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010, Graz, Austria. varun.kushwah@rcpe.at.
Jazyk: angličtina
Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2024 May 15; Vol. 25 (5), pp. 114. Date of Electronic Publication: 2024 May 15.
DOI: 10.1208/s12249-024-02832-8
Abstrakt: There is a growing focus on solid-state degradation, especially for its relevance in understanding interactions with excipients. Performing a solid-state degradation of Venetoclax (VEN), we delve into VEN's stability in different solid-state oxidative stress conditions, utilizing Peroxydone™ complex and urea peroxide (UHP). The investigation extends beyond traditional forced degradation scenarios, providing insights into VEN's behavior over 32 h, considering temperature and crystallinity conditions. Distinct behaviors emerge in the cases of Peroxydone™ complex and UHP. The partially crystalline (PC-VEN) form proves more stable with Peroxydone™, while the amorphous form (A-VEN) shows enhanced stability with UHP. N-oxide VEN, a significant degradation product, varies between these cases, reflecting the impact of different oxidative stress conditions. Peroxydone™ complex demonstrates higher reproducibility and stability, making it a promising option for screening impurities in solid-state oxidative stress scenarios. This research not only contributes to the understanding of VEN's stability in solid-state but also aids formulators in anticipating excipient incompatibilities owing to presence of reactive impurities (peroxides) and oxidation in the final dosage form.
(© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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