DNA-empowered synthetic cells as minimalistic life forms.

Autor: Samanta A; Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany. avik.samanta@nt.iitr.ac.in.; Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, India. avik.samanta@nt.iitr.ac.in., Baranda Pellejero L; Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany., Masukawa M; Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany., Walther A; Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany. andreas.walther@uni-mainz.de.
Jazyk: angličtina
Zdroj: Nature reviews. Chemistry [Nat Rev Chem] 2024 Jun; Vol. 8 (6), pp. 454-470. Date of Electronic Publication: 2024 May 15.
DOI: 10.1038/s41570-024-00606-1
Abstrakt: Cells, the fundamental units of life, orchestrate intricate functions - motility, adaptation, replication, communication, and self-organization within tissues. Originating from spatiotemporally organized structures and machinery, coupled with information processing in signalling networks, cells embody the 'sensor-processor-actuator' paradigm. Can we glean insights from these processes to construct primitive artificial systems with life-like properties? Using de novo design approaches, what can we uncover about the evolutionary path of life? This Review discusses the strides made in crafting synthetic cells, utilizing the powerful toolbox of structural and dynamic DNA nanoscience. We describe how DNA can serve as a versatile tool for engineering entire synthetic cells or subcellular entities, and how DNA enables complex behaviour, including motility and information processing for adaptive and interactive processes. We chart future directions for DNA-empowered synthetic cells, envisioning interactive systems wherein synthetic cells communicate within communities and with living cells.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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