Dysregulation of platelet serotonin, 14-3-3, and GPIX in sudden infant death syndrome.

Autor: Frelinger AL 3rd; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA. Andrew.Frelinger@childrens.harvard.edu.; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston Children's Hospital, Karp 08212, 300 Longwood Avenue, Boston, MA, 02115-5737, USA. Andrew.Frelinger@childrens.harvard.edu., Haynes RL; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Goldstein RD; Robert's Program on Sudden Unexpected Death in Pediatrics, Division of General Pediatrics, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, USA., Berny-Lang MA; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA., Gerrits AJ; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA., Riehs M; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Haas EA; Rady Children's Hospital, San Diego, CA, USA., Paunovic B; County of San Diego Medical Examiner's Office, San Diego, CA, USA., Mena OJ; County of Ventura Medical Examiner's Office, Ventura, CA, USA., Campman SC; County of San Diego Medical Examiner's Office, San Diego, CA, USA., Milne GL; Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA., Sleeper LA; Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Kinney HC; Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Michelson AD; Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 15; Vol. 14 (1), pp. 11092. Date of Electronic Publication: 2024 May 15.
DOI: 10.1038/s41598-024-61949-9
Abstrakt: Sudden infant death syndrome (SIDS) is the leading cause of post-neonatal infant mortality, but the underlying cause(s) are unclear. A subset of SIDS infants has abnormalities in the neurotransmitter, serotonin (5-hydroxytryptamine [5-HT]) and the adaptor molecule, 14-3-3 pathways in regions of the brain involved in gasping, response to hypoxia, and arousal. To evaluate our hypothesis that SIDS is, at least in part, a multi-organ dysregulation of 5-HT, we examined whether blood platelets, which have 5-HT and 14-3-3 signaling pathways similar to brain neurons, are abnormal in SIDS. We also studied platelet surface glycoprotein IX (GPIX), a cell adhesion receptor which is physically linked to 14-3-3. In infants dying of SIDS compared to infants dying of known causes, we found significantly higher intra-platelet 5-HT and 14-3-3 and lower platelet surface GPIX. Serum and plasma 5-HT were also elevated in SIDS compared to controls. The presence in SIDS of both platelet and brainstem 5-HT and 14-3-3 abnormalities suggests a global dysregulation of these pathways and the potential for platelets to be used as a model system to study 5-HT and 14-3-3 interactions in SIDS. Platelet and serum biomarkers may aid in the forensic determination of SIDS and have the potential to be predictive of SIDS risk in living infants.
(© 2024. The Author(s).)
Databáze: MEDLINE
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