Bora-Diaza-Indacene Based Fluorescent Probes for Simultaneous Visualisation of Lipid Droplets and Endoplasmic Reticulum.

Autor: Choi PJ; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag, 92019, Auckland 1142, New Zealand., Tatenaka Y; Dojindo Laboratories Co., Ltd, Techno-Research Park Tabaru 2025-5, Mashiki-machi, Kamimashiki-gun, 861-2202, Japan., Noguchi K; Dojindo Laboratories Co., Ltd, Techno-Research Park Tabaru 2025-5, Mashiki-machi, Kamimashiki-gun, 861-2202, Japan., Ishiyama M; Dojindo Laboratories Co., Ltd, Techno-Research Park Tabaru 2025-5, Mashiki-machi, Kamimashiki-gun, 861-2202, Japan., Denny W; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag, 92019, Auckland 1142, New Zealand., Jose J; Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag, 92019, Auckland 1142, New Zealand.
Jazyk: angličtina
Zdroj: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Jul 02; Vol. 25 (13), pp. e202400415. Date of Electronic Publication: 2024 Jun 24.
DOI: 10.1002/cbic.202400415
Abstrakt: Organelle selective fluorescent probes, especially those capable of concurrent detection of specific organelles, are of benefit to the research community in delineating the interplay between various organelles and the impact of such interaction in maintaining cellular homeostasis and its disruption in the diseased state. Although very useful, such probes are synthetically challenging to design due to the stringent lipophilicity requirement posed by different organelles, and hence, the lack of such probes being reported so far. This work details the synthesis, photophysical properties, and cellular imaging studies of two bora-diaza-indacene based fluorescent probes that can specifically and simultaneously visualise lipid droplets and endoplasmic reticulum; two organelles suggested having close interactions and implicated in stress-induced cellular dysfunction and disease progression.
(© 2024 The Authors. ChemBioChem published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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