Associations between behavioral and self-reported impulsivity, brain structure, and genetic influences in middle childhood.

Autor: Gilman JM; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. Electronic address: jgilman1@mgh.harvard.edu., Kaur J; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA., Tervo-Clemmens B; Department of Psychiatry & Behavioral Science, Masonic Institute for the Developing Brain, Institute for Translational Neuroscience, University of Minnesota, USA., Potter K; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA., Sanzo BT; Massachusetts General Hospital (MGH) Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine, Massachusetts General Hospital (MGH), MA, USA., Schuster RM; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Bjork JM; Institute for Drug and Alcohol Studies, Virginia Commonwealth University, VA, USA., Evins AE; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Roffman JL; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Lee PH; Massachusetts General Hospital (MGH) Department of Psychiatry, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital (MGH) Psychiatric and Neurodevelopmental Genetics Unit Center for Genomic Medicine, Massachusetts General Hospital (MGH), MA, USA.
Jazyk: angličtina
Zdroj: Developmental cognitive neuroscience [Dev Cogn Neurosci] 2024 Jun; Vol. 67, pp. 101389. Date of Electronic Publication: 2024 May 11.
DOI: 10.1016/j.dcn.2024.101389
Abstrakt: Impulsivity undergoes a normative developmental trajectory from childhood to adulthood and is thought to be driven by maturation of brain structure. However, few large-scale studies have assessed associations between impulsivity, brain structure, and genetic susceptibility in children. In 9112 children ages 9-10 from the ABCD study, we explored relationships among impulsivity (UPPS-P impulsive behavior scale; delay discounting), brain structure (cortical thickness (CT), cortical volume (CV), and cortical area (CA)), and polygenic scores for externalizing behavior (PGS EXT ). Both higher UPPS-P total scores and more severe delay-discounting had widespread, low-magnitude associations with smaller CA in frontal and temporal regions. No associations were seen between impulsivity and CV or CT. Additionally, higher PGS EXT was associated with both higher UPPS-P scores and with smaller CA and CV in frontal and temporal regions, but in non-overlapping cortical regions, underscoring the complex interplay between genetics and brain structure in influencing impulsivity. These findings indicate that, within large-scale population data, CA is significantly yet weakly associated with each of these impulsivity measures and with polygenic risk for externalizing behaviors, but in distinct brain regions. Future work should longitudinally assess these associations through adolescence, and examine associated functional outcomes, such as future substance use and psychopathology.
Competing Interests: Declaration of Competing Interest All authors declare no competing interests.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: