Chemical Composition of Extracts and Fractions from Miconia Ibaguensis (Melastomataceae) Leaves and Evaluation of Biological Activities.

Autor: Sehnem GS; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Silva JA; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil., da C Silva T; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Prado DG; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Santiago MB; Antimicrobial Testing Laboratory, Institute of Biomedical Sciences, Universidade Federal de Uberlândia -, MG, Uberlândia, Brazil., O Santos AL; Antimicrobial Testing Laboratory, Institute of Biomedical Sciences, Universidade Federal de Uberlândia -, MG, Uberlândia, Brazil., Martins MM; Laboratory of Nanobiotechnology, Institute of Biotechnology, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Cunha LCS; Bioprospecting Center for Natural Products, Chemistry Department, Federal Institute of Triângulo Mineiro -, MG, Uberaba, Brazil., Sousa RMF; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Romero R; Institute of Biology, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Bittar VP; Laboratory of Biochemistry and Molecular Biology, Institute of Biotechnology, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Borges ALS; Laboratory of Biochemistry and Molecular Biology, Institute of Biotechnology, Federal University of Uberlândia -, MG, Uberlândia, Brazil., Martins CHG; Antimicrobial Testing Laboratory, Institute of Biomedical Sciences, Universidade Federal de Uberlândia -, MG, Uberlândia, Brazil., Espindola FS; Laboratory of Biochemistry and Molecular Biology, Institute of Biotechnology, Federal University of Uberlândia -, MG, Uberlândia, Brazil., de Oliveira A; Nucleus of Research in Natural Products, Institute of Chemistry, Federal University of Uberlândia -, MG, Uberlândia, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Jul; Vol. 21 (7), pp. e202400680. Date of Electronic Publication: 2024 Jun 22.
DOI: 10.1002/cbdv.202400680
Abstrakt: The study aimed to assess the chemical composition of Miconia ibaguensis leaves extracts and fractions obtained from the ethanolic extract (EE), along with evaluating their antifungal, antibacterial, antidiabetic, and antioxidant activities. The ethyl acetate fraction (EAF) exhibited potent antifungal activity against Candida spp (1.95-3.90 μg mL -1 ) and potent antioxidant activity in the DPPH (1.74±0.07 μg mL -1 ), FRAP (654.01±42.09 μmol E Trolox /g sample ), and ORAC (3698.88±37.28 μmol E Trolox /g sample ) methods. The EE displayed inhibition against the α-amylase enzyme (8.42±0.05 μg mL -1 ). Flavonoids, hydrolysable tannins, triterpenoids, and phenolic acids, identified in the EE and fractions via (-)-HPLC-ESI-MS/MS analysis, were found to contribute to the species' biological activity potentially. These findings suggest promising avenues for further research and potential applications in pharmacology and natural products, offering new possibilities in the fight against global health issues.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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