Effects of Vitamin D Supplementation on Central Hemodynamic Parameters and Autonomic Nervous System in Obese or Overweight Individuals.

Autor:	Faria ACC; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Moreira CL; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Cunha MRD; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.; Departamento de Nutrição Aplicada, Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Mattos S; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Oigman W; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil., Neves MF; Departamento de Clínica Médica, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ - Brasil.
Jazyk:	Portuguese; English
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2024 Apr; Vol. 121 (5), pp. e20230678.
DOI:	10.36660/abc.20230678
Abstrakt:	Background: Previous studies have been inconsistent in demonstrating beneficial cardiovascular effects of vitamin D supplementation. Objective: To evaluate the effects of vitamin D3 supplementation on central hemodynamic parameters and autonomic activity in obese/overweight individuals with low vitamin D levels (<30ng/dl). Methods: Adults 40-65 years old with body mass index ≥25<40 kg/m2 were enrolled in this prospective, randomized, double-blind clinical trial (NCT05689632). Central hemodynamics was assessed using the oscillometric method (Mobil-O-Graph®), and heart rate variability using a Polar heart rate monitor (Kubios® software). Patients (n=53) received a placebo in the control group (CO, n=25) or vitamin D3 (VD, n=28) 7000 IU/day, and were evaluated before (W0) and after 8 weeks (W8) with a significance level of 0.05. Results: The groups were homogeneous regarding age (51±6 vs 52±6 years, p=0.509) and vitamin D levels (22.8±4.9 vs 21.7±4.5ng/ml, p=0.590). At W8, the VD group had significantly higher levels of vitamin D (22.5 vs 35.6ng/ml, p<0.001). Only the VD group showed a significant reduction in systolic blood pressure (SBP; 123±15 vs 119±14mmHg, p=0.019) and alkaline phosphatase (213±55 vs 202±55mg/dl, p=0.012). The CO group showed an increase in augmentation pressure (AP: 9 vs 12 mmHg, p=0.028) and augmentation index (AIx: 26 vs 35%, p=0.020), which was not observed in the VD group (AP: 8 vs 8 mmHg, AIx: 26 vs 25%, p>0.05). VD group showed an increase in the parasympathetic nervous system index (PNSi) (-0.64±0.94 vs -0.16±1.10, p=0.028) and the R-R interval (866±138 vs 924±161 ms, p= 0.026). Conclusion: In this sample, eight weeks of daily vitamin D supplementation resulted in an improvement in blood pressure levels and autonomic balance.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu