Microbubble-encapsulated Cobalt Nitrato Complexes for Ultrasound-triggerable Nitric Oxide Delivery.
| Autor: | Koczera P; Institute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany., Thomas F; Institute of Inorganic Chemistry, RWTH Aachen University, Aachen, Germany., Rama E; Institute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany., Thoröe-Boveleth S; Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany., Kiessling F; Institute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany., Lammers T; Institute for Experimental Molecular Imaging, Medical Faculty, RWTH Aachen University, Aachen, Germany., Herres-Pawlis S; Institute of Inorganic Chemistry, RWTH Aachen University, Aachen, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | ChemMedChem [ChemMedChem] 2024 Aug 19; Vol. 19 (16), pp. e202400232. Date of Electronic Publication: 2024 Jun 20. |
| DOI: | 10.1002/cmdc.202400232 |
| Abstrakt: | Cobalt complexes exhibit versatile reactivity with nitric oxide (NO), enabling their utilization in applications ranging from homogeneous catalysis to NO-based modulation of biological processes. However, the coordination geometry around the cobalt center is complex, the therapeutic window of NO is narrow, and controlled NO delivery is difficult. To better understand the complexation of cobalt with NO, we prepared four cobalt nitrato complexes and present a structure-property relationship for ultrasound-triggerable NO release. We hypothesized that modulation of the coordination geometry by ligand-modification would improve responsiveness to mechanical stimuli, like ultrasound. To enable eventual therapeutic testing, we here first demonstrate the in vitro tolerability of [Co(ethylenediamine) (© 2024 The Author(s). ChemMedChem published by Wiley-VCH GmbH.) |
| Databáze: | MEDLINE |
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