Dementia Risk Scores, APOE , and risk of Alzheimer disease: one size does not fit all.
| Autor: | Andrews SJ; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143., Boeriu AI; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143., Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA, 94304.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St.Louis, MO, USA, 63108.; Department of Neurology, Washington University School of Medicine, St.Louis, MO, USA, 63108., Renton AE; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, USA, 10029., Fulton-Howard B; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1428 Madison Ave, New York, NY, USA, 10029., Brenowitz WD; Kaiser Permanente Center for Health Research, 3800 N Interstate Ave, Portland, OR, USA, 97227.; Department of Epidemiology and Biostatistics, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143., Yaffe K; Department of Psychiatry and Behavioral Sciences, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143.; Department of Epidemiology and Biostatistics, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143.; Department of Neurology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, USA, 94143. |
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| Jazyk: | angličtina |
| Zdroj: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 16. Date of Electronic Publication: 2024 Aug 16. |
| DOI: | 10.1101/2024.04.27.24306486 |
| Abstrakt: | Introduction: Evaluating the generalizability of dementia risk scores, primarily developed in non-Latinx White (NLW) participants, and interactions with genetic risk factors in diverse populations is crucial for addressing health disparities. Methods: We analyzed the association of the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) and modified CAIDE (mCAIDE) scores with dementia risk using logistic regression models stratified by race/ethnicity in NACC and ADNI, and assessed their interaction with APOE . Results: Higher CAIDE scores were associated with an increased risk of dementia in Asian, Latinx, and NLW participants but not in Black participants. In contrast, higher mCAIDE scores were also associated with an increased risk of dementia in Black participants. Unfavorable mCAIDE risk profiles exacerbated the APOE *ε4 risk effect and attenuated the APOE *ε2 protective effect. Discussion: Our findings underscore the importance of evaluating the validity of dementia risk scores in diverse populations for their use in personalized medicine approaches to promote brain health. Competing Interests: Conflict of Interest Disclosures The authors report no conflicts of interest. |
| Databáze: | MEDLINE |
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