Intermittent Hypoxia-Induced Enhancements in Corticospinal Excitability Predict Gains in Motor Learning and Metabolic Efficiency.

Autor:	Bogard AT; Sensorimotor Recovery and Neuroplasticity Lab at the University of Colorado, Boulder, Dept. of Integrative Physiology, 80309, USA., Hembree TG; Sensorimotor Recovery and Neuroplasticity Lab at the University of Colorado, Boulder, Dept. of Integrative Physiology, 80309, USA., Pollet AK; Sensorimotor Recovery and Neuroplasticity Lab at the University of Colorado, Boulder, Dept. of Integrative Physiology, 80309, USA., Smith AC; University of Colorado School of Medicine, Dept. of Physical Medicine and Rehabilitation, Aurora, 80045, USA., Ryder SC; Rocky Mountain Regional VA Medical Center, Aurora, 80045, USA., Marzloff G; Rocky Mountain Regional VA Medical Center, Aurora, 80045, USA., Tan AQ; Sensorimotor Recovery and Neuroplasticity Lab at the University of Colorado, Boulder, Dept. of Integrative Physiology, 80309, USA.; Rocky Mountain Regional VA Medical Center, Aurora, 80045, USA.; Center for Neuroscience, University of Colorado, Boulder, 80309, USA.
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2024 Apr 24. Date of Electronic Publication: 2024 Apr 24.
DOI:	10.21203/rs.3.rs-4259378/v1
Abstrakt:	Acute intermittent hypoxia (AIH) enhances human motor function after incomplete spinal cord injury. Although the underlying mechanisms in humans are unknown, emerging evidence indicates that AIH facilitates corticospinal excitability to the upper limb. However, the functional relevance of this plasticity remains unexplored, and it is unclear whether similar plasticity can be induced for lower limb motor areas. We recently demonstrated that AIH improves motor learning and metabolic efficiency during split-belt walking. Thus, we hypothesized that AIH increases lower limb excitability and that these enhancements would predict the magnitude of motor learning and the corresponding reductions in net metabolic power. We assessed tibialis anterior (TA) excitability using transcranial magnetic stimulation and quantified changes in spatiotemporal asymmetries and net metabolic power in response to split-belt speed perturbations. We show that AIH enhances TA excitability, and that the magnitude of this facilitation positively correlates with greater spatiotemporal adaptation. Notably, we demonstrate a novel association between increased excitability and reduced net metabolic power during motor learning and savings. Together, our results suggest that AIH-induced gains in excitability predict both the magnitude of motor learning and the associated metabolic efficiency. Determining indices of AIH-induced improvements in motor performance is critical for optimizing its therapeutic reach. Competing Interests: Additional information The authors declare no competing financial interests.
Databáze:	MEDLINE
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