A multi-organ map of the human immune system across age, sex and ethnicity.

Autor:	Mangiola S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Milton M; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Ranathunga N; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Li-Wai-Suen C; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Odainic A; The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany., Yang E; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Hutchison W; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Garnham A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Iskander J; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Pal B; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia., Yadav V; Systems Biology of Aging Laboratory, Columbia University; New York, USA., Rossello J; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC 3052, Australia.; Novo Nordisk Foundation Center for Stem Cell Medicine, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.; Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia.; Australian Regenerative Medicine Institute, Monash University, Victoria, Australia., Carey VJ; Channing Division of Network Medicine, Mass General Brigham, Harvard Medical School, Harvard University, Boston, USA., Morgan M; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, NY, USA., Bedoui S; The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Kallies A; The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Papenfuss AT; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Apr 29. Date of Electronic Publication: 2024 Apr 29.
DOI:	10.1101/2023.06.08.542671
Abstrakt:	Understanding tissue biology's heterogeneity is crucial for advancing precision medicine. Despite the centrality of the immune system in tissue homeostasis, a detailed and comprehensive map of immune cell distribution and interactions across human tissues and demographics remains elusive. To fill this gap, we harmonised data from 12,981 single-cell RNA sequencing samples and curated 29 million cells from 45 anatomical sites to create a comprehensive compositional and transcriptional healthy map of the healthy immune system. We used this resource and a novel multilevel modelling approach to track immune ageing and test differences across sex and ethnicity. We uncovered conserved and tissue-specific immune-ageing programs, resolved sex-dependent differential ageing and identified ethnic diversity in clinically critical immune checkpoints. This study provides a quantitative baseline of the immune system, facilitating advances in precision medicine. By sharing our immune map, we hope to catalyse further breakthroughs in cancer, infectious disease, immunology and precision medicine. Competing Interests: FJR receives institutional support as a coinvestigator and is subcontracted by the Peter MacCallum Cancer Centre for an investigator-initiated trial, which receives funding support from Sanofi/Regeneron Pharmaceuticals. The remaining authors declare no competing interests.
Databáze:	MEDLINE
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