Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study.

Autor:	Labounek R; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA., Bondy MT; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA., Paulson AL; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA., Bédard S; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada., Abramovic M; Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland., Alonso-Ortiz E; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada., Atcheson NT; Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia., Barlow LR; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Barry RL; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Harvard-Massachusetts Institute of Technology Health Sciences & Technology, Cambridge, Massachusetts, USA., Barth M; Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia.; School of Electrical Engineering and Computer Science, The University of Queensland, St Lucia, Australia., Battiston M; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK., Büchel C; Department for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Budde MD; Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.; Clement J. Zablocki Veteran's Affairs Medical Center, Milwaukee, WI, USA., Callot V; Aix-Marseille Univ, CNRS, CRMBM, Marseille, France.; APHM, Hopital Universitaire Timone, CEMEREM, Marseille, France., Combes A; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK., De Leener B; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada.; Department of Computer Engineering and Software Engineering, Polytechnique Montreal, Montreal, QC, Canada., Descoteaux M; Sherbrooke Connectivity Imaging Lab (SCIL), Computer Science department, Université de Sherbrooke, Sherbrooke, QC, Canada., de Sousa PL; Université de Strasbourg, CNRS, ICube, Strasbourg, France., Dostál M; Department of Radiology and Nuclear Medicine, University Hospital Brno and Masaryk University, Czech Republic.; Department of Biophysics, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Doyon J; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada., Dvorak AV; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada., Eippert F; Max Planck Research Group Pain Perception, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Epperson KR; Stanford University, Stanford, CA, USA., Epperson KS; Stanford University, Stanford, CA, USA., Freund P; Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Wellcome Trust Centre for Neuroimaging, Queen Square Institute of Neurology, University College London, London, UK.; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany., Finsterbusch J; Department for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Foias A; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada., Fratini M; Institute of Nanotechnology, CNR, Rome, Italy.; IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy., Fukunaga I; Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo, Tokyo 113-8421, Japan., Gandini Wheeler-Kingshott CAM; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK.; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy., Germani G; Advanced Imaging and Artificial Intelligence Center, Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy., Gilbert G; MR Clinical Science, Philips Healthcare Canada, Mississauga, Canada., Giove F; IRCCS Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy.; CREF - Museo storico della fisica e Centro studi e ricerche Enrico Fermi, Rome, Italy., Grussu F; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK.; Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain., Hagiwara A; Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo, Tokyo 113-8421, Japan., Henry PG; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Horák T; Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Department of Neurology, University Hospital Brno, Brno, Czech Republic.; Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czech Republic., Hori M; Department of Radiology, Juntendo University School of Medicine, 1-2-1, Hongo, Bunkyo, Tokyo 113-8421, Japan.; Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan., Joers JM; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Kamiya K; Department of Radiology, Toho University Omori Medical Center, Tokyo, Japan., Karbasforoushan H; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Keřkovský M; Department of Radiology and Nuclear Medicine, University Hospital Brno and Masaryk University, Czech Republic., Khatibi A; Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), University of Birmingham, Birmingham, UK.; Centre for Human Brain Health, University of Birmingham, Birmingham, UK.; Institute for Mental Health, University of Birmingham, Birmingham, UK., Kim JW; Biomedical Engineering and Imaging Institute, Department of Radiology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Radiology, Baylor College of Medicine, Houston, Texas, USA.; Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA., Kinany N; Neuro-X Institute, Ecole polytechnique fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Switzerland., Kitzler H; Institute of Diagnostic and Interventional Neuroradiology, Faculty of Medicine and Carl Gustav Carus University Hospital, Technische Universität Dresden, Germany., Kolind S; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.; Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Kong Y; CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Science, Beijing, 100101, China.; Department of Psychology, University of Chinese Academy of Sciences, Beijing, 100049, China., Kudlička P; Multimodal and Functional Imaging Laboratory, Central European Institute of Technology, Brno, Czech Republic.; First Department of Neurology, St. Anne's University Hospital and Medical Faculty of Masaryk University, Brno, Czech Republic., Kuntke P; Institute of Diagnostic and Interventional Neuroradiology, Faculty of Medicine and Carl Gustav Carus University Hospital, Technische Universität Dresden, Germany., Kurniawan ND; Centre for Advanced Imaging, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia., Kusmia S; IBM Poland, Department of Content Design, Cracow, Poland., Laganà MM; Canon Medical Systems srl, Rome, Italy., Laule C; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.; Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, Canada.; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada., Law CSW; Stanford University, Stanford, CA, USA., Leutritz T; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany., Liu Y; Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, China., Llufriu S; Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic Barcelona, Fundació de Recerca Clínic Barcelona-IDIBAPS and Universitat de Barcelona. Barcelona, Spain., Mackey S; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Martin AR; Department of Neurological Surgery, University of California, Davis, CA, USA., Martinez-Heras E; Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic Barcelona, Fundació de Recerca Clínic Barcelona-IDIBAPS and Universitat de Barcelona. Barcelona, Spain.; Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Mattera L; Fondation Campus Biotech Geneva, Genève, Switzerland., O'Grady KP; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA., Papinutto N; Department of Neurology, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Papp D; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.; Wellcome Centre For Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Pareto D; Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Parrish TB; Department of Radiology, Northwestern University, Chicago, IL 60611, USA., Pichiecchio A; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Advanced Imaging and Artificial Intelligence Center, Neuroradiology Department, IRCCS Mondino Foundation, Pavia, Italy., Prados F; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK.; e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain.; Centre for Medical Image Computing, University College London, London, UK., Rovira À; Section of Neuroradiology, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Ruitenberg MJ; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Australia., Samson RS; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK., Savini G; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072, Pieve Emanuele (MI), Italy.; Neuroradiology Unit, IRCCS Humanitas Research Hospital, Via Alessandro Manzoni 56, 20089, Rozzano (MI), Italy., Seif M; Spinal Cord Injury Center Balgrist, University Hospital Zurich, University of Zurich, Zurich, Switzerland.; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany., Seifert AC; Biomedical Engineering and Imaging Institute, Department of Radiology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA., Smith AK; Wellcome Centre For Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Smith SA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN USA., Smith ZA; Department of Neurosurgery, University of Oklahoma, Oklahoma City, OK, USA., Solana E; Neuroimmunology and Multiple Sclerosis Unit, Laboratory of Advanced Imaging in Neuroimmunological Diseases (ImaginEM), Hospital Clinic Barcelona, Fundació de Recerca Clínic Barcelona-IDIBAPS and Universitat de Barcelona. Barcelona, Spain., Suzuki Y; The University of Tokyo Hospital, Radiology Center, Tokyo, Japan., Tackley GW; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, Wales, UK., Tinnermann A; Department for Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Valošek J; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.; Mila - Quebec AI Institute, Montreal, QC, Canada.; Department of Neurosurgery, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic.; Department of Neurology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Olomouc, Czech Republic., Van De Ville D; Neuro-X Institute, Ecole polytechnique fédérale de Lausanne, Geneva, Switzerland.; Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Switzerland., Yiannakas MC; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK., Weber KA 2nd; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Weiskopf N; Wellcome Trust Centre for Neuroimaging, Queen Square Institute of Neurology, University College London, London, UK.; Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany.; Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Linnéstraße 5, 04103 Leipzig, Germany., Wise RG; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, Wales, UK.; Department of Neurosciences, Imaging, and Clinical Sciences, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Institute for Advanced Biomedical Technologies, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy., Wyss PO; Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland., Xu J; Biomedical Engineering and Imaging Institute, Department of Radiology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.; Department of Radiology, Baylor College of Medicine, Houston, Texas, USA.; Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA., Cohen-Adad J; NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.; Centre de recherche du CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada.; Mila - Quebec AI Institute, Montreal, QC, Canada.; Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, Canada., Lenglet C; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA., Nestrašil I; Division of Clinical Behavioral Neuroscience, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.; Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 May 01. Date of Electronic Publication: 2024 May 01.
DOI:	10.1101/2024.04.29.591421
Abstrakt:	Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject's sex and age. However, corrections for body size (i.e. height and weight) are mostly lacking in clinical neuroimaging designs. This study investigates the importance of body size parameters in their relationship with spinal cord (SC) and brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population of 267 healthy human adults (age 30.1±6.6 years old, 125 females). We show that body height correlated strongly or moderately with brain gray matter (GM) volume, cortical GM volume, total cerebellar volume, brainstem volume, and cross-sectional area (CSA) of cervical SC white matter (CSA-WM; 0.44≤r≤0.62). In comparison, age correlated weakly with cortical GM volume, precentral GM volume, and cortical thickness (-0.21≥r≥-0.27). Body weight correlated weakly with magnetization transfer ratio in the SC WM, dorsal columns, and lateral corticospinal tracts (-0.20≥r≥-0.23). Body weight further correlated weakly with the mean diffusivity derived from diffusion tensor imaging (DTI) in SC WM (r=-0.20) and dorsal columns (-0.21), but only in males. CSA-WM correlated strongly or moderately with brain volumes (0.39≤r≤0.64), and weakly with precentral gyrus thickness and DTI-based fractional anisotropy in SC dorsal columns and SC lateral corticospinal tracts (-0.22≥r≥-0.25). Linear mixture of sex and age explained 26±10% of data variance in brain volumetry and SC CSA. The amount of explained variance increased at 33±11% when body height was added into the mixture model. Age itself explained only 2±2% of such variance. In conclusion, body size is a significant biological variable. Along with sex and age, body size should therefore be included as a mandatory variable in the design of clinical neuroimaging studies examining SC and brain structure. Competing Interests: Declaration of interests Since June 2022, Dr. A.K. Smith has been employed by GE HealthCare. This article was co-authored by Dr. Smith in his personal capacity. The opinions expressed in the article are his in and do not necessarily reflect the views of GE HealthCare. Since August 2022, Dr. M. M. Laganà has been employed by Canon Medical Systems srl, Rome, Italy. This article was co-authored by Dr. M. M. Laganà in her personal capacity. The opinions expressed in the article are her own and do not necessarily reflect the views of Canon Medical Systems. Since September 2023, Dr. Papp has been an employee of Siemens Healthcare AB, Sweden. This article was co-authored by Dr. Papp in his personal capacity. The views and opinions expressed in this article are his own and do not necessarily reflect the views of Siemens Healthcare AB, or Siemens Healthineers AG. Since January 2024, Dr. Barry has been employed by the National Institute of Biomedical Imaging and Bioengineering at the NIH. This article was co-authored by Robert Barry in his personal capacity. The opinions expressed in the article are his own and do not necessarily reflect the views of the NIH, the Department of Health and Human Services, or the United States government. Guillaume Gilbert is an employee of Philips Healthcare. S Llufriu received compensation for consulting services and speaker honoraria from Biogen Idec, Novartis, Bristol Myer Squibb Genzyme, Sanofi Jansen and Merck. The Max Planck Institute for Human Cognitive and Brain Sciences and Wellcome Centre for Human Neuroimaging have institutional research agreements with Siemens Healthcare. NW holds a patent on acquisition of MRI data during spoiler gradients (US 10,401,453 B2). NW was a speaker at an event organized by Siemens Healthcare and was reimbursed for the travel expenses. The other authors declare no competing interests.
Databáze:	MEDLINE
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