Are single nucleotide polymorphisms in the IL-2 gene biomarkers for Hashimoto's thyroiditis?

Autor: Chiorean AD; Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Emergency Clinical Hospital for Children, Cluj-Napoca, Romania., Bâlici Ş; Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Nicula GZ; Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Vică ML; Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Legal Medicine Institute Cluj-Napoca, Cluj-Napoca, Romania., Nechita VI; Department of Medical Informatics and Biostatistics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Loga LI; Clinical Institute of Urology and Renal Transplantation, Cluj-Napoca, Romania., Bordea MA; Department of Microbiology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Simon LM; Department of Microbiology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Matei HV; Department of Cell and Molecular Biology, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.; Legal Medicine Institute Cluj-Napoca, Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Medicine and pharmacy reports [Med Pharm Rep] 2024 Apr; Vol. 97 (2), pp. 178-183. Date of Electronic Publication: 2024 Apr 25.
DOI: 10.15386/mpr-2739
Abstrakt: Background and Aims: Hashimoto's thyroiditis (HT) is an autoimmune disorder that can lead to hypothyroidism. The pathophysiology of HT involves the production of antithyroid antibodies that attack the thyroid tissue, causing inflammation and progressive fibrosis. Recent studies demonstrated a strong correlation between Interleukin-2 (IL-2) levels and the development of autoimmune diseases, suggesting that this cytokine may play a crucial role in the pathogenesis of HT.
Methods: In this study, we determined the presence of the point mutation +114T/G in the IL-2 gene in patients with HT compared with a control group, and also the serum level of anti-thyroid peroxidase (TPOAbs) and anti-thyroglobulin (TgAbs) antibodies in HT patients with vs. without the mutation. The sequences of the IL-2 gene obtained from subjects were determined by the Sanger sequencing method.
Results: Our study did not reveal that the +114T/G polymorphism of the IL-2 gene is a susceptibility or protective factor for HT. No significant correlations were observed between the reference genotype, hetero- and homozygous +114T/G polymorphism and TPOAbs, respectively TgAbs serum levels in HT patients.
Conclusions: Further studies of more cases are needed to identify more polymorphisms in the IL-2 gene and study their correlations with HT.
Databáze: MEDLINE
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