Distinct cytokine profiles in late pregnancy in Ugandan people with HIV.

Autor: Bebell LM; Medical Practice Evaluation Center and Center for Global Health, Massachusetts General Hospital Division of Infectious Diseases, GRJ-504, 55 Fruit St, Boston, MA, 02114, USA. lbebell@mgh.harvard.edu., Ngonzi J; Department of Obstetrics and Gynaecology, Mbarara University of Science and Technology, Mbarara, Uganda., Butler A; State University of New York Upstate Medical University, Syracuse, NY, USA., Kumbakumba E; Department of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda., Adong J; Department of Paediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda., Loos C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Boatin AA; Department of Obstetrics and Gynecology and Center for Global Health, Massachusetts General Hospital, Boston, MA, USA., Bassett IV; Division of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Siedner MJ; Division of Infectious Diseases and Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA., Williams PL; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Mattie H; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hedt-Gauthier B; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA., Correia KFB; Department of Mathematics and Statistics, Amherst College, Amherst, MA, USA., Lake E; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Alter G; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 May 14; Vol. 14 (1), pp. 10980. Date of Electronic Publication: 2024 May 14.
DOI: 10.1038/s41598-024-61764-2
Abstrakt: During pregnancy, multiple immune regulatory mechanisms establish an immune-tolerant environment for the allogeneic fetus, including cellular signals called cytokines that modify immune responses. However, the impact of maternal HIV infection on these responses is incompletely characterized. We analyzed paired maternal and umbilical cord plasma collected during labor from 147 people with HIV taking antiretroviral therapy and 142 HIV-uninfected comparators. Though cytokine concentrations were overall similar between groups, using Partial Least Squares Discriminant Analysis we identified distinct cytokine profiles in each group, driven by higher IL-5 and lower IL-8 and MIP-1α levels in pregnant people with HIV and higher RANTES and E-selectin in HIV-unexposed umbilical cord plasma (P-value < 0.01). Furthermore, maternal RANTES, SDF-α, gro α -KC, IL-6, and IP-10 levels differed significantly by HIV serostatus (P < 0.01). Although global maternal and umbilical cord cytokine profiles differed significantly (P < 0.01), umbilical cord plasma profiles were similar by maternal HIV serostatus. We demonstrate that HIV infection is associated with a distinct maternal plasma cytokine profile which is not transferred across the placenta, indicating a placental role in coordinating local inflammatory response. Furthermore, maternal cytokine profiles in people with HIV suggest an incomplete shift from Th2 to Th1 immune phenotype at the end of pregnancy.
(© 2024. The Author(s).)
Databáze: MEDLINE
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