Plasma and interstitial fluid antibiotic levels of subcutaneously implanted compounded florfenicol calcium sulfate beads in New Zealand White rabbits (Oryctolagus cuniculus).

Autor:	Partyka M; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA., Divers S; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA., Cruz-Espindola C; Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL., Weyna AAW; Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA., Gottdenker NL; Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA., Burns L; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA., Trumpp K; Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA., Boothe DM; Department of Anatomy, Physiology, and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL.; Veterinary Information Network, Davis, CA.
Jazyk:	angličtina
Zdroj:	American journal of veterinary research [Am J Vet Res] 2024 May 18; Vol. 85 (7). Date of Electronic Publication: 2024 May 18 (Print Publication: 2024).
DOI:	10.2460/ajvr.24.02.0044
Abstrakt:	Objective: To determine antibiotic levels in plasma and interstitial fluid (ISF) after SC placement of compounded florfenicol (FF) calcium sulfate beads (CSBs) in New Zealand White rabbits (Oryctolagus cuniculus). Animals: 6 juvenile female rabbits (n = 5 treatment and 1 control). Methods: An ultrafiltration probe and CSBs were placed SC in 6 rabbits (n = 5 for FF CSBs and 1 for control CSBs). Plasma (3, 6, 12, 24, and 48 hours and 7, 14, and 21 days) and ISF (daily for 21 days) samples were collected, and FF was measured by HPLC for pharmacokinetic analysis. Hematology, biochemistry, and histopathology were assessed. Results: Means ± SD for the area under the curve, maximum concentration, time of maximum concentration, terminal half-life, and mean residence time to the last data point for plasma and ISF were 16.63 ± 8.16 and 17,902 ± 7,564 h·µg/mL, 0.79 ± 0.38 and 245 ± 223 µg/mL, 2.90 ± 0.3 and 59 ± 40 hours, 30.81 ± 16.9 and 27.3 ± 9.39 hours, 23.4 ± 10 and 73.7 ± 13 hours, respectively. Plasma FF was < 2 µg/mL at all time points. The ISF FF remained > 8 μg/mL for 109.98 to 231.58 hours. One rabbit death occurred during treatment, but the cause of death was undetermined. Local tissue inflammation was present, but no clinically significant systemic adverse effects were found on hematology, biochemistry, or histopathology in the remaining rabbits. Clinical Relevance: Florfenicol CSBs maintained antibiotic concentrations in ISF at levels likely to be effective against bacteria sensitive to > 8 µg/mL for 5 to 10 days while maintaining low (< 2 µg/mL) plasma levels. Florfenicol CSBs may be effective for local antibiotic treatment in rabbit abscesses.
Databáze:	MEDLINE
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