Comparative metabolite analysis of Piper sarmentosum organs approached by LC-MS-based metabolic profiling.

Autor: Ware I; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany.; Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, Kota Kinabalu 88400, Sabah, Malaysia.; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia., Franke K; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany. kfranke@ipb-halle.de.; Institute of Biology/Geobotany and Botanical Garden, Martin Luther University Halle-Wittenberg, 06108, Halle (Saale), Germany. kfranke@ipb-halle.de.; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, 04103, Leipzig, Germany. kfranke@ipb-halle.de., Frolov A; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany., Bureiko K; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany., Kysil E; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany., Yahayu M; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia., El Enshasy HA; Institute of Bioproduct Development, Universiti Teknologi Malaysia (UTM), 81310 Johor Bahru, Johor, Malaysia.; City of Scientific Research and Technology Applications, New Borg Al Arab, Alexandria, 21934, Egypt., Wessjohann LA; Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, 06120, Halle (Saale), Germany. wessjohann@ipb-halle.de.; German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, 04103, Leipzig, Germany. wessjohann@ipb-halle.de.
Jazyk: angličtina
Zdroj: Natural products and bioprospecting [Nat Prod Bioprospect] 2024 May 14; Vol. 14 (1), pp. 30. Date of Electronic Publication: 2024 May 14.
DOI: 10.1007/s13659-024-00453-z
Abstrakt: Piper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subtropical regions of Asia, offering both health and culinary benefits. In this study the secondary metabolites in different organs of P. sarmentosum were identified and their relative abundances were characterized. The metabolic profiles of leaves, roots, stems and fruits were comprehensively investigated by liquid chromatography high-resolution mass spectrometry (LC-HR-MS) and the data subsequently analyzed using multivariate statistical methods. Manual interpretation of the tandem mass spectrometric (MS/MS) fragmentation patterns revealed the presence of 154 tentatively identified metabolites, mostly represented by alkaloids and flavonoids. Principle component analysis and hierarchical clustering indicated the predominant occurrence of flavonoids, lignans and phenyl propanoids in leaves, aporphines in stems, piperamides in fruits and lignan-amides in roots. Overall, this study provides extensive data on the metabolite composition of P. sarmentosum, supplying useful information for bioactive compounds discovery and patterns of their preferential biosynthesis or storage in specific organs. This can be used to optimize production and harvesting as well as to maximize the plant's economic value as herbal medicine or in food applications.
(© 2024. The Author(s).)
Databáze: MEDLINE
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