Incidence of primary hepatitis C infection among people who inject drugs during 2012-2020 in Athens, Greece.

Autor: Roussos S; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Bagos C; Sotiria General Hospital, Athens, Greece., Angelopoulos T; Gastroenterology Department, General Hospital of Athens Korgialeneio - Mpenakeio Hellenic Red Cross, Athens, Greece., Chaikalis S; Hellenic Scientific Society for the Study of AIDS, Sexually Transmitted and Emerging Diseases, Athens, Greece., Cholongitas E; First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Savvanis S; Department of Internal Medicine, General Hospital of Athens 'Elpis', Athens, Greece., Papadopoulos N; 2nd Department of Internal Medicine, 401 General Army Hospital of Athens, Athens, Greece., Kapatais A; 1st Department of Internal Medicine, Western Attica General Hospital 'Agia Varvara', Athens, Greece., Chounta A; 4th Department of Internal Medicine, General University Hospital 'Attikon', Athens, Greece., Ioannidou P; Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Deutsch M; 2nd Academic Department of Internal Medicine, Hippokration General Hospital, Athens, Greece., Manolakopoulos S; 2nd Academic Department of Internal Medicine, Hippokration General Hospital, Athens, Greece., Sevastianos V; 4th Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece., Papageorgiou MV; Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Vlachogiannakos I; Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Mela M; Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece., Elefsiniotis I; Department of Internal Medicine-Hepatogastroenterology, 'Agioi Anargyroi' General and Oncology Hospital, National and Kapodistrian University of Athens, Athens, Greece., Vrakas S; Department of Gastroenterology, Tzaneion General Hospital of Piraeus, Piraeus, Greece., Karagiannakis D; Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Pliarchopoulou F; 4th Department of Internal Medicine, General University Hospital 'Attikon', Athens, Greece., Psichogiou M; First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Paraskevis D; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Vickerman P; Population Health Sciences, University of Bristol, Bristol, UK., Malliori M; Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece., Kalamitsis G; Hellenic Liver Patients Association 'Prometheus', Athens, Greece., Papatheodoridis G; Academic Department of Gastroenterology, Medical School of National and Kapodistrian University of Athens, General Hospital of Athens 'Laiko', Athens, Greece., Hatzakis A; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.; Hellenic Scientific Society for the Study of AIDS, Sexually Transmitted and Emerging Diseases, Athens, Greece., Sypsa V; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk: angličtina
Zdroj: Journal of viral hepatitis [J Viral Hepat] 2024 Aug; Vol. 31 (8), pp. 466-476. Date of Electronic Publication: 2024 May 14.
DOI: 10.1111/jvh.13951
Abstrakt: One of the World Health Organization's targets for the 2030 viral hepatitis elimination strategy is to reduce new hepatitis C (HCV) infections. In Athens, Greece, people who inject drugs (PWID) have a high HCV prevalence, with increasing trends since the 2000s. This analysis aims to assess primary HCV incidence among PWID during 2012-2020. Two community-based interventions were implemented in 2012-2013 and 2018-2020 with repeated sero-behavioural surveys in each period. Participants enrolled in multiple surveys were identified through linkage. To assess trends in HCV transmission, three indicators were estimated: (i) anti-HCV prevalence among 'new' injectors (those injecting ≤2 years), (ii) indirect HCV incidence among 'new' injectors, assuming infection occurred at the midpoint between initiating injection and the first positive test, and (iii) HCV incidence from repeat participants. There were 431 and 125 'new' injectors, respectively, in 2012-2013 and 2018-2020. Αnti-HCV prevalence [95% CI] declined from 53.6% [48.8%, 58.3%] in 2012-2013 to 40.0% [31.3, 49.1%] in 2018-2020 (25.4% reduction, p = .007). The indirect estimate [95% CI] of HCV incidence among 'new' injectors decreased from 56.1 [49.3, 63.8] to 39.0/100 person-years (PYs) [29.6, 51.5] (30.5% reduction, p = .020). HCV incidence [95% CI] based on seroconversions in repeat participants (16/63 in 2012-2013 and 9/55 in 2018-2020) declined from 64.6 [39.6105.4] to 13.8/100 PYs [7.2, 26.5], respectively (78.6% reduction, p < .001). Primary HCV incidence remains high among PWID in Athens. Consistent implementation of combined interventions, including high-coverage harm reduction programs and initiatives tailored to increase access to HCV treatment, is essential to sustain the declining trends documented during 2012-2020.
(© 2024 The Authors. Journal of Viral Hepatitis published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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