Thymic carcinoma presenting with overlap polyarthritis and myositis: A rare paraneoplastic syndrome in childhood.

Autor: Yıldız Ç; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Türkcan BT; Department of Pediatric Oncology, Gazi University Faculty of Medicine, Ankara, Turkey., Vural Ö; Department of Pediatric Oncology, Gazi University Faculty of Medicine, Ankara, Turkey., Gezgin Yıldırım D; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., İnan MA; Department of Medical Pathology, Gazi University Faculty of Medicine, Ankara, Turkey., Poyraz A; Department of Medical Pathology, Gazi University Faculty of Medicine, Ankara, Turkey., Pınarlı FG; Department of Pediatric Oncology, Gazi University Faculty of Medicine, Ankara, Turkey., Taştepe İ; Department of Thoracic Surgery, Gazi University Faculty of Medicine, Ankara, Turkey., Demir E; Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey., Sunar Yayla EN; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Esmeray Şenol P; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Karaçayır N; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Bakkaloğlu SA; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2024 May; Vol. 27 (5), pp. e15187.
DOI: 10.1111/1756-185X.15187
Abstrakt: Thymic tumors are very rare neoplasms in children and account for less than 1% of mediastinal tumors in pediatric patients. One-third of the pediatric patients present with symptoms related to the compression of the tumor mass on the surrounding anatomic structures, and paraneoplastic syndromes such as myasthenia gravis, pure red cell aplasia, acquired hypogammaglobulinemia, and connective tissue disorders, which rarely occur in children with thymic tumors. Herein, we report a case of thymic carcinoma mimicking the symptoms of a connective tissue disease with symmetrical polyarthritis accompanying myositis, fever, weight loss, and malaise in a 15-year-old male patient. To our knowledge, this is the first case pediatric thymic carcinoma accompany with severe polyarthritis and myopathy, thus we have reviewed the current literature regarding the cases of thymic malignancies coexisting with paraneoplastic syndromes in children.
(© 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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