Association Between Smoking and Lipid Profile in Men Aged 35 to 70 Years: Dose-Response Analysis.

Autor:	Moosazadeh M; Gastrointestitional Cancer Research Center, Non-Communicable Disease Institute, Mazandaran University of Medical Sciences, Sari, Iran., Ebrahimnejad P; Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.; Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran., Kheradmand M; Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran., Modanloo M; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Mardanshah F; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Mahboobi S; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Rostamian M; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Safajoo A; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Dehghanzadegan M; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran., Kianmehr F; Deputy of Research and Technology, Mazandaran University of Medical Sciences, Sari, Iran.
Jazyk:	angličtina
Zdroj:	American journal of men's health [Am J Mens Health] 2024 May-Jun; Vol. 18 (3), pp. 15579883241249655.
DOI:	10.1177/15579883241249655
Abstrakt:	Dyslipidemia is linked to various health complications, including cardiovascular disease and inflammation. This study aimed to assess the association between smoking and lipid profile in the Tabari cohort population. Data from the Tabari Cohort Study involving 4,149 men were analyzed. A standardized questionnaire collected smoking history, while blood samples measured lipid levels and anthropometric measurements were recorded. Statistical analysis utilized chi-square tests and logistic regression, adjusting for potential confounders. The prevalence of smoking was 893 (21.52%; urban: 20.6%, mountainous: 23.8%, significant level: .024). The adjusted odds ratio (OR) of low high-density lipoprotein (HDL) among smokers 1.48 (95% confidence interval [CI]: 1.25-1.77, p < .001) was the same as non-smokers. The adjusted OR of high low-density lipoprotein (LDL) in men with 1 to 10, 11 to 20, and more than 20 cigarettes per day was 0.95 (95% CI: 0.73-1.25), 1.30 (95% CI: 0.99-1.71), and 2.64 (95% CI: 1.32-5.27) and low HDL was equal to 1.34 (95% CI: 1.06-1.68), 1.61 (95% CI: 1.26-2.05), and 2.24 (95% CI: 1.13-4.42) compared with non-smokers, respectively. The study findings indicate that smoking is associated with lower HDL levels, even after adjusting for potential confounders. The odds of low HDL and high LDL increases with higher smoking intensity. The low HDL and high LDL levels in individuals smoking over 20 cigarettes/day, respectively, show a 2.24-fold and a 2.64-fold increased odds compared to non-smokers. These findings highlight the importance of smoking cessation in relation to lipid profiles and related health risks. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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