| Autor: |
Duarte WE; Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil.; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Pinho JD; State University of Maranhão, Zé Doca, Brazil.; Oncology Research Center, Federal University of Pará, Belém, Brazil., Melo SPDC; Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil.; University Hospital, Federal University of Maranhão, São Luís, Brazil., Duarte DRD; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Carmo JMDGRD; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil., Khayat AS; Oncology Research Center, Federal University of Pará, Belém, Brazil., Calixto JRR; University Hospital, Federal University of Maranhão, São Luís, Brazil., Campos MAG; Clinical Hospital of Medical School, São Paulo, State University, Unesp, Botucatu, São Paulo, Brazil., Correa RDGCF; Postgraduate Program in Nursing, Federal University of Maranhão, Maranhão, Brazil., Júnior AMA; Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil., Teixeira-Júnior AAL; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil.; Department of Genetics and Postgraduate Program in Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil., Silva GEB; Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil.; Clinical Research Center, University Hospital of the Federal University of Maranhão, São Luís, Brazil.; Postgraduate Program in Health Science, Federal University of Maranhão, Maranhão, Brazil.; Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. |
| Abstrakt: |
The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes ( p = 0.001), while its expression was associated with high-grade tumors ( p = 0.014), histological subtype ( p = 0.001), presence of sarcomatoid transformation ( p = 0.04), and perineural invasion ( p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis. |
