Circadian dysfunction and cardio-metabolic disorders in humans.
| Autor: | Marhefkova N; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia.; First Faculty of Medicine, Charles University, Prague, Czechia., Sládek M; Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia., Sumová A; Institute of Physiology, The Czech Academy of Sciences, Prague, Czechia., Dubsky M; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czechia.; First Faculty of Medicine, Charles University, Prague, Czechia. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 Apr 29; Vol. 15, pp. 1328139. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024). |
| DOI: | 10.3389/fendo.2024.1328139 |
| Abstrakt: | The topic of human circadian rhythms is not only attracting the attention of clinical researchers from various fields but also sparking a growing public interest. The circadian system comprises the central clock, located in the suprachiasmatic nucleus of the hypothalamus, and the peripheral clocks in various tissues that are interconnected; together they coordinate many daily activities, including sleep and wakefulness, physical activity, food intake, glucose sensitivity and cardiovascular functions. Disruption of circadian regulation seems to be associated with metabolic disorders (particularly impaired glucose tolerance) and cardiovascular disease. Previous clinical trials revealed that disturbance of the circadian system, specifically due to shift work, is associated with an increased risk of type 2 diabetes mellitus. This review is intended to provide clinicians who wish to implement knowledge of circadian disruption in diagnosis and strategies to avoid cardio-metabolic disease with a general overview of this topic. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Marhefkova, Sládek, Sumová and Dubsky.) |
| Databáze: | MEDLINE |
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