Alterations in Gut Microbiota as Early Biomarkers for Predicting Inflammatory Bowel Disease Onset and Progression: A Systematic Review.

Autor:	Boppana K; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Internal Medicine, Manipal University, Manipal, IND., Almansouri NE; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Internal Medicine, University of Tripoli, Tripoli, LBY., Bakkannavar S; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Faheem Y; Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Medicine, New Medical Center Royal Hospital, Abu Dhabi, ARE., Jaiswal A; Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA., Shergill K; Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.; Medicine, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, IND., Nath TS; Surgical Oncology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Apr 11; Vol. 16 (4), pp. e58080. Date of Electronic Publication: 2024 Apr 11 (Print Publication: 2024).
DOI:	10.7759/cureus.58080
Abstrakt:	Inflammatory bowel disease (IBD) is a chronic ailment impacting the digestive system, triggered by an unusual reaction of the immune system. It includes two types of diseases: ulcerative colitis and Crohn's disease. Nonetheless, the diagnosis and evaluation of disease progression in IBD are difficult due to the absence of distinct indicators. While conventional biomarkers from blood plasma and feces, such as C-reactive protein, fecal calprotectin, and S100A12, can be employed to gauge inflammation, they are not exclusive to IBD. There is a broad consensus that intestinal microorganisms significantly contribute to the onset of intestinal imbalance, a condition intimately linked with the cause and development of IBD. Numerous studies have indicated that the makeup of intestinal microorganisms varies between individuals with IBD and those who are healthy, particularly concerning the diversity of microbes and the proportional prevalence of certain bacteria. A total of 1475 records underwent examination. Following the eligibility assessment, 17 reports were considered. The final review encompassed 12 studies, as five articles were excluded due to insufficient details regarding cases, controls, and comparability. This article suggests that gut microbiota has potential biomarkers for the noninvasive evaluation of IBD activity. Recognizing the microbiome linked with disease activity paves the way for the development of a group of microbiota-derived indicators to evaluate the initiation and advancement of IBD. This article discusses whether changes in gut microbial composition can serve as early indicators of IBD onset and progression. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Boppana et al.)
Databáze:	MEDLINE
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