Injectable 2D Material-Based Sensor Array for Minimally Invasive Neural Implants.

Autor: Kim J; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Hong J; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Park K; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Lee S; gBrain Inc., Incheon, 21984, Republic of Korea., Hoang AT; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Pak S; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Zhao H; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Ji S; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Yang S; Department of Nanobioengineering, Incheon National University, Incheon, 22012, Republic of Korea., Chung CK; Department of Neurosurgery, Seoul National University Hospital, Seoul, 03080, Republic of Korea.; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea., Yang S; gBrain Inc., Incheon, 21984, Republic of Korea.; Department of Neuroscience, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong., Ahn JH; School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (32), pp. e2400261. Date of Electronic Publication: 2024 May 21.
DOI: 10.1002/adma.202400261
Abstrakt: Intracranial implants for diagnosis and treatment of brain diseases have been developed over the past few decades. However, the platform of conventional implantable devices still relies on invasive probes and bulky sensors in conjunction with large-area craniotomy and provides only limited biometric information. Here, an implantable multi-modal sensor array that can be injected through a small hole in the skull and inherently spread out for conformal contact with the cortical surface is reported. The injectable sensor array, composed of graphene multi-channel electrodes for neural recording and electrical stimulation and MoS 2 -based sensors for monitoring intracranial temperature and pressure, is designed based on a mesh structure whose elastic restoring force enables the contracted device to spread out. It is demonstrated that the sensor array injected into a rabbit's head can detect epileptic discharges on the surface of the cortex and mitigate it by electrical stimulation while monitoring both intracranial temperature and pressure. This method provides good potential for implanting a variety of functional devices via minimally invasive surgery.
(© 2024 The Authors. Advanced Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: